右美沙芬-安非他酮能减轻抑郁症患者的精神疼痛吗?生成假设概述视角。

IF 3.6 3区 医学 Q1 PSYCHIATRY
Maurizio Pompili, Isabella Berardelli, Denise Erbuto, Filippo Caraci
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引用次数: 0

摘要

在全球范围内,重度抑郁症(MDD)是导致残疾的主要原因。它会对社会交往产生负面影响,严重限制日常功能,最终降低生活满意度。女性的患病率大约是男性的两倍。据认为,重度抑郁症的成因是复杂的,包括生物、遗传、环境和心理因素。精神痛苦,虽然是可区分的,但却构成了重度抑郁症(MDD)的一个关键框架,因为这两者可能会引发自杀风险。在Panksepp的情绪理论中概念化的精神痛苦,在考虑阿片系统的关键作用时尤其相关,阿片系统可以影响与悲伤和分离相关的感觉。针对阿片类药物系统进行重度抑郁症的抗抑郁治疗和缓解精神疼痛的研究重新引起了人们的兴趣。具有部分mu-阿片受体(MOR)激动作用和kappa-阿片受体(KOR)拮抗作用的抗抑郁药物可能是解决MDD患者未满足需求的新药理学工具。右美沙芬和安非他酮联合使用是一种耐受性良好、见效快的治疗选择,适用于成年重度抑郁症患者。我们假设右美沙芬-安非他酮可以通过靶向阿片系统来减轻重度抑郁症患者的精神疼痛,Panksepp的理论支持了这一假设。右美沙芬与安非他酮联用可以治疗精神疼痛的各个方面,可能改善治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can dextromethorphan-bupropion reduce mental pain in depressed individuals? A generating hypothesis overview perspective.

Globally, major depressive disorder, or MDD, is a leading cause of disability. It negatively impacts social interactions and significantly limits daily functioning, ultimately reducing life satisfaction. The prevalence rate is about twice as high in women as in males. It is believed that the genesis of major depressive disorder is complicated and includes biological, genetic, environmental, and psychological factors. Mental pain, although distinguishable, constitutes a crucial framework in major depressive disorder (MDD) as the pair may precipitate suicide risk. Mental pain, as conceptualized in Panksepp's emotional theory, is especially relevant when considering the key role of the opioid system, which can influence feelings tied to grief and separation. There has been a renewed interest in targeting the opioid system for antidepressant treatment in MDD and to soothe mental pain. Antidepressant drugs endowed with partial mu-opioid receptor (MOR) agonism and kappa-opioid receptor (KOR) antagonism might represent novel pharmacological tools to address unmet needs in MDD patients. The combination of dextromethorphan and bupropion is a well-tolerated, rapid-acting treatment option for adults affected by MDD. We hypothesized that dextromethorphan-bupropion could impact the reduction of mental pain in MDD patients by targeting the opioid system, as supported by Panksepp's theory. The combination of dextromethorphan with bupropion might deal with various aspects of mental pain, possibly improving treatment results.

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来源期刊
CiteScore
6.60
自引率
2.70%
发文量
43
审稿时长
>12 weeks
期刊介绍: Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.
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