中国西南地区19种微量元素水平与前列腺癌相关性的病例对照研究

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biological Trace Element Research Pub Date : 2025-10-01 Epub Date: 2025-03-17 DOI:10.1007/s12011-025-04563-8
Maoling Zhan, Yujing Chuai, Xiaotao Zhou, Jia Li, Xianghong Zhou, Zilong Zhang, Yuming Jin, Weichao Huang, Xinyi Huang, Siqing He, Hongyan Zeng, Shi Qiu, Xiaoli Zou
{"title":"中国西南地区19种微量元素水平与前列腺癌相关性的病例对照研究","authors":"Maoling Zhan, Yujing Chuai, Xiaotao Zhou, Jia Li, Xianghong Zhou, Zilong Zhang, Yuming Jin, Weichao Huang, Xinyi Huang, Siqing He, Hongyan Zeng, Shi Qiu, Xiaoli Zou","doi":"10.1007/s12011-025-04563-8","DOIUrl":null,"url":null,"abstract":"<p><p>Prostate cancer (PCa) is the most prevalent urological malignancy, exhibiting the highest incidence and the second-highest mortality among all male cancers. The incidence of PCa in men in China is consistently rising. Studies have shown that elemental exposure levels are associated with the occurrence of PCa. However, epidemiological data are limited, and more researches on different regions and races are needed. To clarify the relationship between the occurrence of PCa and serum levels of 19 trace elements. Serum samples from 79 PCa patients and 74 male healthy controls were obtained, and the levels of 19 trace elements were measured using inductively coupled plasma mass spectrometry (ICP-MS). Baseline matching of key demographic characteristics was performed between the two groups. The relationship between serum trace elements levels and PCa, prostate-specific antigen (PSA), and PCa staging were evaluated using the Mann-Whitney U test, logistic regression, and Spearman's correlation analysis. Statistical analysis of the test results revealed that the low levels of Cu, Zn, and Se in serum may be associated with the development of PCa. Moreover, the changes in the interrelationship of trace elements may play a role in the development of PCa.</p>","PeriodicalId":8917,"journal":{"name":"Biological Trace Element Research","volume":" ","pages":"5081-5095"},"PeriodicalIF":3.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Case-Control Study of Association Between Serum Levels of 19 Trace Elements with Prostate Cancer in Southwest China.\",\"authors\":\"Maoling Zhan, Yujing Chuai, Xiaotao Zhou, Jia Li, Xianghong Zhou, Zilong Zhang, Yuming Jin, Weichao Huang, Xinyi Huang, Siqing He, Hongyan Zeng, Shi Qiu, Xiaoli Zou\",\"doi\":\"10.1007/s12011-025-04563-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Prostate cancer (PCa) is the most prevalent urological malignancy, exhibiting the highest incidence and the second-highest mortality among all male cancers. The incidence of PCa in men in China is consistently rising. Studies have shown that elemental exposure levels are associated with the occurrence of PCa. However, epidemiological data are limited, and more researches on different regions and races are needed. To clarify the relationship between the occurrence of PCa and serum levels of 19 trace elements. Serum samples from 79 PCa patients and 74 male healthy controls were obtained, and the levels of 19 trace elements were measured using inductively coupled plasma mass spectrometry (ICP-MS). Baseline matching of key demographic characteristics was performed between the two groups. The relationship between serum trace elements levels and PCa, prostate-specific antigen (PSA), and PCa staging were evaluated using the Mann-Whitney U test, logistic regression, and Spearman's correlation analysis. Statistical analysis of the test results revealed that the low levels of Cu, Zn, and Se in serum may be associated with the development of PCa. Moreover, the changes in the interrelationship of trace elements may play a role in the development of PCa.</p>\",\"PeriodicalId\":8917,\"journal\":{\"name\":\"Biological Trace Element Research\",\"volume\":\" \",\"pages\":\"5081-5095\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological Trace Element Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s12011-025-04563-8\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Trace Element Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s12011-025-04563-8","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

前列腺癌(PCa)是最常见的泌尿系统恶性肿瘤,在所有男性癌症中发病率最高,死亡率第二高。中国男性前列腺癌发病率持续上升。研究表明,元素暴露水平与PCa的发生有关。然而,流行病学资料有限,需要对不同地区和种族进行更多的研究。目的:探讨前列腺癌的发生与血清19种微量元素含量的关系。采集79例前列腺癌患者和74例男性健康对照者的血清样本,采用电感耦合等离子体质谱法(ICP-MS)测定19种微量元素的含量。在两组之间进行关键人口统计学特征的基线匹配。采用Mann-Whitney U检验、logistic回归和Spearman相关分析评估血清微量元素水平与前列腺癌、前列腺特异性抗原(PSA)和前列腺癌分期的关系。对检测结果进行统计分析,提示血清中Cu、Zn、Se水平低可能与前列腺癌的发生有关。此外,微量元素相互关系的变化可能在PCa的发展中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Case-Control Study of Association Between Serum Levels of 19 Trace Elements with Prostate Cancer in Southwest China.

Prostate cancer (PCa) is the most prevalent urological malignancy, exhibiting the highest incidence and the second-highest mortality among all male cancers. The incidence of PCa in men in China is consistently rising. Studies have shown that elemental exposure levels are associated with the occurrence of PCa. However, epidemiological data are limited, and more researches on different regions and races are needed. To clarify the relationship between the occurrence of PCa and serum levels of 19 trace elements. Serum samples from 79 PCa patients and 74 male healthy controls were obtained, and the levels of 19 trace elements were measured using inductively coupled plasma mass spectrometry (ICP-MS). Baseline matching of key demographic characteristics was performed between the two groups. The relationship between serum trace elements levels and PCa, prostate-specific antigen (PSA), and PCa staging were evaluated using the Mann-Whitney U test, logistic regression, and Spearman's correlation analysis. Statistical analysis of the test results revealed that the low levels of Cu, Zn, and Se in serum may be associated with the development of PCa. Moreover, the changes in the interrelationship of trace elements may play a role in the development of PCa.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信