5-外皮和10-外皮β-丝氨酸及5-外皮和10-外皮肋片的合成及其对灭螨螨的杀螨活性。

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-05-21 DOI:10.1093/bbb/zbaf034

Kento Miura, Kenji Nemoto, Hirosato Takikawa, Yusuke Ogura

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引用次数: 0

摘要

以二氢香芹酮为原料合成了5-外皮-和10-外皮-β-selinene以及5-外皮-和10-外皮-肋片，其中硒酸酯的自由基环化是构建癸酮骨架的关键步骤。并对(+)-costal和(+)-β-selinene非对映体的杀螨活性进行了评价。其中，10-外肋叶的杀螨活性最强。

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Synthesis of 5-epi- and 10-epi-β-selinenes and 5-epi- and 10-epi-costals and their acaricidal activity against Varroa destructor.

Synthesis of 5-epi- and 10-epi-β-selinenes and 5-epi- and 10-epi-costals was achieved from dihydrocarvone, involving the radical cyclization of selenoester to construct a decalone framework as the key step. The acaricidal activities of these diastereomers of (+)-costal and (+)-β-selinene were also evaluated against Varroa destructor. Among them, 10-epi-costal exhibited the most potent acaricidal activity.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).