磁性富集和纳米银加合物促进表面增强拉曼散射对肿瘤抑制基因启动子的精确甲基化检测（Small 11/2025）

IF 12.1 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-03-19 DOI:10.1002/smll.202570080

Shubham Singh, Yu-Wei Lin, Wen-Jyun Wang, Yu-Cheng Chang, Yi-Hsin Chien, Wei-Peng Li

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引用次数: 0

摘要

甲基化检测基因加合物修饰的银簇能够特异性标记肿瘤抑制子启动子上的甲基化位点。这种尖端的系统利用基因杂交纳米珠进行磁富集，确保靶向和高效的基因样品制备。银促进的表面增强拉曼散射放大了5-甲基胞嘧啶信号，而甲基化和未甲基化启动子周围的局部热点确保了精确的甲基化检测。文章编号2407517，钱益新，李伟鹏及其同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Precise Methylation Detection of Tumor Suppressor Gene Promoters by Magnetic Enrichment and Nano Silver Adduct–Promoted Surface-Enhanced Raman Scattering (Small 11/2025)

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Precise Methylation Detection of Tumor Suppressor Gene Promoters by Magnetic Enrichment and Nano Silver Adduct–Promoted Surface-Enhanced Raman Scattering (Small 11/2025)

Methylation Detection

The gene adduct-modified silver cluster enables specific labeling of the methylation site on the tumor suppressor promoter. This cutting-edge system utilizes gene-hybridizable nanobeads for magnetic enrichment, ensuring targeted and efficient gene sample preparation. Silver-promoted surface-enhanced Raman scattering amplifies the 5-methyl cytosine signal, while localized hot spots around methylated and unmethylated promoters ensure precise methylation detection. More in article number 2407517, Yi-Hsin Chien, Wei-Peng Li, and co-workers.

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.