{"title":"呼气气溶胶中d -葡萄糖分子的实时检测使用生化传感器呼气分析仪应用","authors":"Pardis Sadeghi;Nader Lobandi;Rania Alshawabkeh;Amie Rui;William Sun;Juntong Chen;Bin Luo;Rui Huang;Nian X. Sun","doi":"10.1109/LSENS.2025.3546084","DOIUrl":null,"url":null,"abstract":"The growing prevalence of chronic diseases, such as diabetes, underscores the need for rapid, noninvasive monitoring technologies, as conventional methods are frequently invasive. Exhaled breath aerosol provides a noninvasive alternative to blood sampling for glucose monitoring, but its dilute nature demands highly sensitive sensors for micromolar-level detection. This study presents a novel biosensor utilizing a molecularly imprinted polymer designed to selectively target D-glucose molecules from exhaled breath aerosols. The sensor underwent thorough testing across a range of aerosolized glucose concentrations and was validated using exhaled breath condensate (EBC) samples from healthy subjects, utilizing a 3-D printed breathalyzer device. The findings demonstrate a significant correlation between D-glucose levels in EBC (aerosols) and sensor resistance.","PeriodicalId":13014,"journal":{"name":"IEEE Sensors Letters","volume":"9 4","pages":"1-4"},"PeriodicalIF":2.2000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Real-Time Detection of D-Glucose Molecules in Exhaled Aerosols Using a Biochemical Sensor for Breathalyzer Applications\",\"authors\":\"Pardis Sadeghi;Nader Lobandi;Rania Alshawabkeh;Amie Rui;William Sun;Juntong Chen;Bin Luo;Rui Huang;Nian X. Sun\",\"doi\":\"10.1109/LSENS.2025.3546084\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The growing prevalence of chronic diseases, such as diabetes, underscores the need for rapid, noninvasive monitoring technologies, as conventional methods are frequently invasive. Exhaled breath aerosol provides a noninvasive alternative to blood sampling for glucose monitoring, but its dilute nature demands highly sensitive sensors for micromolar-level detection. This study presents a novel biosensor utilizing a molecularly imprinted polymer designed to selectively target D-glucose molecules from exhaled breath aerosols. The sensor underwent thorough testing across a range of aerosolized glucose concentrations and was validated using exhaled breath condensate (EBC) samples from healthy subjects, utilizing a 3-D printed breathalyzer device. The findings demonstrate a significant correlation between D-glucose levels in EBC (aerosols) and sensor resistance.\",\"PeriodicalId\":13014,\"journal\":{\"name\":\"IEEE Sensors Letters\",\"volume\":\"9 4\",\"pages\":\"1-4\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-03-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE Sensors Letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://ieeexplore.ieee.org/document/10924313/\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Sensors Letters","FirstCategoryId":"1085","ListUrlMain":"https://ieeexplore.ieee.org/document/10924313/","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Real-Time Detection of D-Glucose Molecules in Exhaled Aerosols Using a Biochemical Sensor for Breathalyzer Applications
The growing prevalence of chronic diseases, such as diabetes, underscores the need for rapid, noninvasive monitoring technologies, as conventional methods are frequently invasive. Exhaled breath aerosol provides a noninvasive alternative to blood sampling for glucose monitoring, but its dilute nature demands highly sensitive sensors for micromolar-level detection. This study presents a novel biosensor utilizing a molecularly imprinted polymer designed to selectively target D-glucose molecules from exhaled breath aerosols. The sensor underwent thorough testing across a range of aerosolized glucose concentrations and was validated using exhaled breath condensate (EBC) samples from healthy subjects, utilizing a 3-D printed breathalyzer device. The findings demonstrate a significant correlation between D-glucose levels in EBC (aerosols) and sensor resistance.