呼气气溶胶中d -葡萄糖分子的实时检测使用生化传感器呼气分析仪应用

IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC
Pardis Sadeghi;Nader Lobandi;Rania Alshawabkeh;Amie Rui;William Sun;Juntong Chen;Bin Luo;Rui Huang;Nian X. Sun
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引用次数: 0

摘要

糖尿病等慢性疾病的日益流行强调了对快速、非侵入性监测技术的需求,因为传统方法往往是侵入性的。呼气气溶胶为血糖监测提供了一种非侵入性的血液采样替代方法,但其稀释的性质需要高灵敏度的传感器进行微摩尔水平检测。本研究提出了一种新型的生物传感器,利用分子印迹聚合物来选择性地靶向呼出气溶胶中的d -葡萄糖分子。该传感器经过了一系列雾化葡萄糖浓度的全面测试,并使用健康受试者的呼出冷凝水(EBC)样本进行了验证,并使用3d打印呼气测醉仪设备。研究结果表明,EBC(气溶胶)中的d -葡萄糖水平与传感器电阻之间存在显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Real-Time Detection of D-Glucose Molecules in Exhaled Aerosols Using a Biochemical Sensor for Breathalyzer Applications
The growing prevalence of chronic diseases, such as diabetes, underscores the need for rapid, noninvasive monitoring technologies, as conventional methods are frequently invasive. Exhaled breath aerosol provides a noninvasive alternative to blood sampling for glucose monitoring, but its dilute nature demands highly sensitive sensors for micromolar-level detection. This study presents a novel biosensor utilizing a molecularly imprinted polymer designed to selectively target D-glucose molecules from exhaled breath aerosols. The sensor underwent thorough testing across a range of aerosolized glucose concentrations and was validated using exhaled breath condensate (EBC) samples from healthy subjects, utilizing a 3-D printed breathalyzer device. The findings demonstrate a significant correlation between D-glucose levels in EBC (aerosols) and sensor resistance.
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来源期刊
IEEE Sensors Letters
IEEE Sensors Letters Engineering-Electrical and Electronic Engineering
CiteScore
3.50
自引率
7.10%
发文量
194
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