胎盘衍生物在生物医学研究中的革命性作用

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2025-03-19 DOI:10.1016/j.bioactmat.2025.03.011

Saeid Moghassemi , Saba Nikanfar , Arezoo Dadashzadeh , Maria João Sousa , Yuting Wan , Fengxuan Sun , Arthur Colson , Sven De Windt , Lena Kwaspen , Marc Kanbar , Keyvan Sobhani , Jie Yang , Hanne Vlieghe , Yongqian Li , Frédéric Debiève , Christine Wyns , Christiani A. Amorim

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引用次数: 0

摘要

人类胎盘是一个短暂而又重要的器官，在维持母体和胎儿之间的关系中发挥着关键作用。尽管胎盘在历史上被归类为 "生物垃圾"，但自 20 世纪初以来，胎盘组织因其巨大的医学潜力，尤其是在伤口修复和外科应用方面的潜力，而受到越来越多的关注。在许多国家，有关人类胎盘衍生物的伦理问题已基本得到解决，由于其在生物医学工程、再生医学和药理学等多个生物医学领域的广泛应用，它们已获得了极大的关注。此外，在实验室研究中使用人类胎盘衍生物替代各种动物产品已成为大势所趋，这反映了人们对推进道德和可持续研究方法的广泛承诺。这篇综述全面审视了人类胎盘衍生物的当前应用，探讨了其治疗效果背后的机制，并概述了这一快速发展领域的未来潜力和方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The revolutionary role of placental derivatives in biomedical research

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The revolutionary role of placental derivatives in biomedical research

The human placenta is a transient yet crucial organ that plays a key role in sustaining the relationship between the maternal and fetal organisms. Despite its historical classification as “biowaste," placental tissues have garnered increasing attention since the early 1900s for their significant medical potential, particularly in wound repair and surgical application. As ethical considerations regarding human placental derivatives have largely been assuaged in many countries, they have gained significant attention due to their versatile applications in various biomedical fields, such as biomedical engineering, regenerative medicine, and pharmacology. Moreover, there is a substantial trend toward various animal product substitutions in laboratory research with human placental derivatives, reflecting a broader commitment to advancing ethical and sustainable research methodologies. This review provides a comprehensive examination of the current applications of human placental derivatives, explores the mechanisms behind their therapeutic effects, and outlines the future potential and directions of this rapidly advancing field.

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.