超越类风湿关节炎：类风湿关节炎中焦虑和抑郁障碍患病率的荟萃分析

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-03-13 DOI:10.1016/j.jpsychires.2025.03.020

Dalainey H. Drakes , Emily J. Fawcett , Justine J.J. Yick , Ashlee R.L. Coles , Rowan B. Seim , Kaitlyn Miller , Madison S. LaSaga , Jonathan M. Fawcett

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引用次数: 0

摘要

类风湿性关节炎（RA）患者中焦虑和抑郁障碍的患病率存在异质性，报道分别为2.4% ~ 85.2%和15% ~ 73.2%。本研究对类风湿性关节炎患者的焦虑和抑郁障碍进行了荟萃分析和终生评估。方法在线检索PubMed、PsycINFO、CINAHL、WoS。在确定的3801篇文章中，分别有13篇和22篇研究被编码为RA中焦虑或抑郁障碍的患病率。如果研究前瞻性地检查了患有类风湿性关节炎的个体（年龄为16岁），采用半结构化诊断访谈，并报告了终生或当前的焦虑或抑郁障碍共病，则纳入研究。结果采用贝叶斯多层次建模方法对数据进行分析，显示当前和终生焦虑障碍患病率分别为13.5%,95%（9.2-17.3）和22.2%,95%（15.9-29.1）。模型还显示，当前和终生抑郁症患病率分别为17.9%和32.4%，分别为ci95%（10.1-27.1）和ci95%（18.3-47.6）。调节分析显示，广泛性焦虑症和重度抑郁症的发病率高于其他焦虑症或抑郁症。局限性：由于估计过少，无法对几个调节因子进行广泛的建模，也无法对需要更多代表性的人口进行详尽的比较，如男性、非白人参与者和年轻成年RA发病人群。结论RA伴发焦虑和抑郁障碍的患病率和风险极高。常规筛查和持续监测RA患者的共病焦虑和抑郁障碍对支持改善预后很重要。

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Beyond rheumatoid arthritis: A meta-analysis of the prevalence of anxiety and depressive disorders in rheumatoid arthritis

Background

The prevalence of anxiety and depressive disorders in patients with rheumatoid arthritis (RA) is heterogenous with reports from 2.4 % to 85.2 % and 15 %–73.2 %, respectively. The present study provides meta-analytic current, and lifetime estimates of anxiety and depressive disorders amongst those living with RA.

Method

An online search of PubMed, PsycINFO, CINAHL, and WoS was conducted. Of the 3801 articles identified, 13 and 22 studies were coded for anxiety or depressive disorder prevalence in RA, respectively. Studies were included if they prospectively examined individuals (age >16) with RA, used semi-structured diagnostic interviews, and reported lifetime or current anxiety or depressive disorder comorbidity.

Results

Data were analyzed using a Bayesian multilevel modelling approach, revealing current and lifetime prevalence of anxiety disorders to be 13.5 % CI_{95 %} (9.2–17.3) and 22.2 %, CI_{95 %} (15.9–29.1), respectively. Models also demonstrated the current and lifetime prevalence of depressive disorders to be 17.9 % CI_{95 %} (10.1–27.1) and 32.4 %, CI_{95 %} (18.3–47.6), respectively. Moderator analyses revealed numerically greater rates of GAD and MDD than other anxiety or depressive disorders.

Limitations

There were too few estimates to extensively model several moderators or to conduct exhaustive comparisons of demographic populations requiring greater representation such as males, non-White participants, and people with young adult RA onset.

Conclusions

The prevalence and risk for comorbid anxiety and depressive disorders in RA is extremely high. Routine screening and ongoing monitoring of individuals with RA for comorbid anxiety and depressive disorders is important to support improved prognosis.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;