抗抑郁药物治疗后炎性细胞因子的变化及其与抑郁症状的相关性

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-03-14 DOI:10.1016/j.jpsychires.2025.02.062

Manle Yin , Heng Zhou , Jin Li , Lianzi Wang , Ming Zhu , Ning Wang , Ping Yang , Zhongming Yang

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引用次数: 0

摘要

本研究旨在探讨抑郁症患者治疗前后血清IL-1、IL-6、IL-10、TNF-a、高敏c反应蛋白（hs-CRP）水平及其与抑郁症临床症状的相关性。方法选择芜湖市第四人民医院新确诊、未治疗的抑郁症患者50例作为抑郁组，同期健康人群50例作为对照组。我们对比了两组中这些炎症标志物的血清水平。在SSRI抗抑郁治疗8周后，评估抑郁组炎症因子、hs-CRP和HAMD-17评分的变化。结果抑郁症患者血清炎症因子、hs-CRP水平显著高于健康对照组(P <；0.05)。治疗后，抑郁症患者血清炎症因子、hs-CRP水平显著降低(P <；0.05)。抑郁组HAMD-17总分及睡眠、认知障碍、抑制、焦虑躯体化因子得分均低于治疗前(P <；0.01)。抑郁症组血清IL-1浓度与HAMD-17抑制因子降低呈负相关（R =−0.359,P = 0.011）；血清IL-6浓度变化率与HAMD-17认知功能障碍因子降低率呈正相关（R = 0.426,P = 0.017）；hs-CRP浓度变化率与HAMD-17焦虑躯体化因子降低率呈正相关（R = 0.343,P = 0.015）。结论抗抑郁治疗显著影响血清炎症因子和hs-CRP水平，并与临床症状的改变相关。

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The change of inflammatory cytokines after antidepressant treatment and correlation with depressive symptoms

Background

The objective of this study was to explore the serum levels of IL-1, IL-6, IL-10, TNF-a, and high-sensitivity C-reactive protein (hs-CRP) in patients with depression before and after treatment and their correlation with the clinical symptoms of depression.

Methods

Fifty depression patients newly diagnosed and untreated in the Fourth People's Hospital of Wuhu were chosen as the depression group, while 50 healthy individuals from the same period served as the control group. We contrasted the serum levels of these markers of inflammation in both groups. After 8 weeks of SSRI antidepressant therapy, changes in inflammatory cytokines, hs-CRP, and HAMD-17 scores were evaluated in the depression group.

Results

The levels of serum inflammatory cytokines and hs-CRP in patients with depression were higher than the healthy control group significantly (P < 0.05). After treatment, the levels of serum inflammatory cytokines and hs-CRP in patients with depression decreased significantly (P < 0.05). The total score of HAMD-17 and the scores of sleep, cognitive impairment, inhibition, and anxiety somatization factors in the depression group were decreased than those before treatment (P < 0.01). The serum IL-1 concentration in the depression group inversely related to the decrease in the HAMD-17 inhibition factor (R = −0.359,P = 0.011); The serum IL-6 concentration change rate positively correlated with the reduction rate of the cognitive impairment factor of HAMD-17 (R = 0.426,P = 0.017); the change rate of hs-CRP concentration was positively correlated with the reduction rate of the anxiety somatization factor of HAMD-17 (R = 0.343,P = 0.015).

Conclusion

Antidepressant treatment affects the levels of serum inflammatory cytokines and hs-CRP significantly, and is correlated with changes in clinical symptoms.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;