TOPAS在低能x射线治疗机剂量计算中的应用

IF 1.6 3区物理与天体物理 Q2 NUCLEAR SCIENCE & TECHNOLOGY

Radiation Measurements Pub Date : 2025-03-14 DOI:10.1016/j.radmeas.2025.107415

S. Ahmadi , T. Monajemi

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引用次数: 0

摘要

TOPAS（粒子模拟工具）是一个蒙特卡罗工具，最初设计用于模拟质子治疗机。本研究旨在探讨TOPAS在模拟正压治疗机中的适用性和准确性。对Xstrahl 300直流电机进行了仿真。在100、180和300 kVp条件下计算光谱、半值层（HVLs）、百分比深度剂量（pdd）、剂量曲线和后向散射因子。此外，在不同的治疗位置，对5厘米直径的场尺寸进行了颅脑CT（计算机断层扫描）上的三维剂量分布评估。在适用的情况下，与其他测量或计算方法进行比较。”采用TrackLengthEstimator方法研究感兴趣区域的剂量分布。光谱，除了荧光峰，符合SpekPy （x射线光谱计算器）的计算。hvl、pdd和剂量谱与临床测量结果一致。四种场尺寸（1、3、5和10厘米直径）和所有能量的后向散射因子与已发表的数据一致（差约2%）。临床CT集上剂量分布和剂量体积直方图的可视化是可访问的功能。TOPAS是一个强大的蒙特卡罗模拟工具，用于模拟正电压治疗单元，可以在临床计划中实现3D剂量分布的可视化。

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Application of TOPAS in dose calculations of low energy X-ray therapy machines

TOPAS (TOol for PArticle Simulation) is a Monte Carlo tool initially designed for simulating proton therapy machines. This study aims to investigate TOPAS’s applicability and accuracy in simulating orthovoltage therapy machine. An Xstrahl 300 orthovoltage machine was simulated. Spectra, HVLs (Half Value Layers), PDDs (Percentage Depth Doses), dose profiles, and backscatter factors were calculated for 100, 180, and 300 kVp. In addition, 3D (Three-Dimensional) dose distributions on a cranial CT (Computed Tomography) were assessed for a 5 cm diameter field size in different treatment locations. Where applicable, comparisons against other measurements or calculations are presented. ”TrackLengthEstimator” method was employed to investigate the dose distributions in regions of interest. Spectra, except for fluorescent peaks, agree with SpekPy (An X-ray spectrum calculator) calculations. HVLs, PDDs, and dose profiles show agreement with clinical measurements. Backscatter factors for four field sizes (1, 3, 5, and 10 cm diameter) and all energies show agreement (difference <2%) with published data. Visualization of dose distributions and DVHs (Dose Volume Histograms) on clinical CT sets are accessible functionalities. TOPAS is a robust Monte Carlo simulation tool for simulations of an orthovoltage treatment unit and could allow accessible visualization of 3D dose distributions in clinical plans.

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来源期刊

Radiation Measurements 工程技术-核科学技术

CiteScore

4.10

自引率

20.00%

发文量

116

审稿时长

48 days

期刊介绍： The journal seeks to publish papers that present advances in the following areas: spontaneous and stimulated luminescence (including scintillating materials, thermoluminescence, and optically stimulated luminescence); electron spin resonance of natural and synthetic materials; the physics, design and performance of radiation measurements (including computational modelling such as electronic transport simulations); the novel basic aspects of radiation measurement in medical physics. Studies of energy-transfer phenomena, track physics and microdosimetry are also of interest to the journal. Applications relevant to the journal, particularly where they present novel detection techniques, novel analytical approaches or novel materials, include: personal dosimetry (including dosimetric quantities, active/electronic and passive monitoring techniques for photon, neutron and charged-particle exposures); environmental dosimetry (including methodological advances and predictive models related to radon, but generally excluding local survey results of radon where the main aim is to establish the radiation risk to populations); cosmic and high-energy radiation measurements (including dosimetry, space radiation effects, and single event upsets); dosimetry-based archaeological and Quaternary dating; dosimetry-based approaches to thermochronometry; accident and retrospective dosimetry (including activation detectors), and dosimetry and measurements related to medical applications.