斯匹次卑尔根地区多形Coniochaeta polymorpha分离株对两性霉素B抗性升高的首次报道

IF 2.9 3区生物学 Q2 MYCOLOGY

Fungal biology Pub Date : 2025-03-09 DOI:10.1016/j.funbio.2025.101567

Jakub Suchodolski, Mateusz Parol, Magdalena Cal-Smok, Agata Piecuch, Rafał Ogórek

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引用次数: 0

摘要

该研究检测了从斯匹次卑尔根驯鹿粪便中分离的多形coniocheta菌株，重点研究了它们的生长特性、抗真菌抗性谱和酶活性。值得注意的是，所有菌株对氟康唑均表现出较高的耐药水平（MIC, 256 μg/mL），表明这是一种内在性状。两性霉素B的敏感性各不相同，一些菌株显示高MIC值，表明出现耐药性。这种现象在受人类活动影响最小的极地生态系统中尤为明显。此外，酶促实验显示其具有显著的蛋白水解和酯酶活性，以及部分α-溶血作用，表明其毒力增强。系统发育分析证实了6个分离菌株的遗传多样性，突出了物种内不同的分支。这些发现有助于了解多形菌的致病潜力和生态多样性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

First report of increased amphotericin B resistance in Coniochaeta polymorpha isolates from Rangifer tarandus platyrhynchus droppings in Spitsbergen

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First report of increased amphotericin B resistance in Coniochaeta polymorpha isolates from Rangifer tarandus platyrhynchus droppings in Spitsbergen

The study examines Coniochaeta polymorpha strains isolated from reindeer droppings in Spitsbergen, focusing on their growth characteristics, antifungal resistance profiles, and enzymatic activities. Notably, all strains exhibited high resistance to fluconazole (MIC, 256 μg/mL), suggesting an inherent trait. Amphotericin B sensitivity varied, with some strains showing high MIC values, indicating emerging resistance. This occurrence is notable in polar ecosystems, which are minimally impacted by human activity. Moreover, enzymatic assays revealed significant proteolytic and esterase activities, as well as partial α-hemolysis, suggesting enhanced virulence potential in C. polymorpha. Phylogenetic analysis confirmed genetic diversity among six isolated strains, highlighting distinct clades within the species. These findings contribute to understanding C. polymorpha pathogenic potential and ecological versatility.

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来源期刊

Fungal biology MYCOLOGY-

CiteScore

5.80

自引率

4.00%

发文量

审稿时长

49 days

期刊介绍： Fungal Biology publishes original contributions in all fields of basic and applied research involving fungi and fungus-like organisms (including oomycetes and slime moulds). Areas of investigation include biodeterioration, biotechnology, cell and developmental biology, ecology, evolution, genetics, geomycology, medical mycology, mutualistic interactions (including lichens and mycorrhizas), physiology, plant pathology, secondary metabolites, and taxonomy and systematics. Submissions on experimental methods are also welcomed. Priority is given to contributions likely to be of interest to a wide international audience.