人乳头瘤病毒在异性恋夫妇中的发病率和接种状况的传播

IF 4 3区医学 Q2 VIROLOGY

Journal of Clinical Virology Pub Date : 2025-03-11 DOI:10.1016/j.jcv.2025.105779

Alissa Moore , Mariam El-Zein , Ann N. Burchell , Pierre-Paul Tellier , François Coutlée , Eduardo L. Franco

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引用次数: 0

摘要

背景了解人乳头瘤病毒（HPV）在夫妻之间的传播动态对于优化疫苗追赶策略是必要的。我们使用来自HPV疫苗减少和预防传播（TRAP-HPV）研究的数据来估计性别特异性发病率和传播率。TRAP-HPV研究招募了加拿大蒙特利尔18岁以上的新（≤6个月）异性恋夫妇（2014-2022）。本研究采用2 × 2因子设计。参与者（n = 308）被随机分为四组：伴侣都不接种HPV疫苗，只有男性伴侣接种HPV疫苗，只有女性伴侣接种HPV疫苗，或者伴侣双方都接种HPV疫苗。在0、2、4、6、9和12个月时收集生殖器样本，对36种HPV型进行基因分型。我们对疫苗靶向型HPV（6/11/16/18/31/33/45/52/58）以及与疫苗靶向型相关（35/39/44/59/67/68/70）和不相关（26/34/40/42/51/53/54/56/61/62/66/ 71/72/73/81/82/83/84/89）的HPV进行了时间-事件分析，以类型特异性HPV感染为分析单位。结果参与者平均年龄为25.5岁（SD 6.0），平均有6个（IQR: 2-15）终生性伴侣。在男性中，接种疫苗的两组男性的发病率（以事件/1000个月计）分别为0.99 （95% CI: 0.17-3.07）和1.67 (95% CI: 0.75-3.51)，而未接种疫苗的男性组的发病率分别为2.42 （95% CI: 0.97-7.63）和3.35 （95% CI: 1.95-6.30）。三个HPV组的结果相似。结论：在女性中没有一致的预防HPV检测的模式，也没有迹象表明最近接种疫苗与不一致夫妇的低传播或对伴侣的保护有关。研究结果不应推广到更年轻的人群。

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Human papillomavirus incidence and transmission by vaccination status among heterosexual couples

Background

Understanding human papillomavirus (HPV) transmission dynamics within couples is necessary for optimal vaccine catch-up strategies. We used data from the Transmission Reduction and Prevention with HPV Vaccination (TRAP-HPV) study to estimate sex-specific incidence and transmission rates.

Methods

The TRAP-HPV study enrolled (2014–2022) new (≤6 months) heterosexual couples aged 18+ in Montreal, Canada. The study employed a 2 × 2 factorial design. Participants (n = 308) were randomized into four groups: neither partner vaccinated against HPV, only the male partner vaccinated against HPV, only the female partner vaccinated against HPV, or both partners vaccinated against HPV. Genital samples, collected at 0, 2, 4, 6, 9, and 12 months, were genotyped for 36 HPV types. We performed time-to-event analyses for vaccine-targeted HPVs (6/11/16/18/31/33/45/52/58) and HPVs phylogenetically related (35/39/44/59/67/68/70) and unrelated (26/34/40/42/51/53/54/56/61/62/66/69/71/72/73/81/82/83/84/89) to vaccine-targeted types, using type-specific HPV infections as the unit of analysis.

Results

Participants had a mean age of 25.5 years (SD 6.0), and a median of 6 (IQR: 2–15) lifetime sexual partners. Among males, incidence rates (in events/1000 months) were 0.99 (95 % CI: 0.17–3.07) and 1.67 (95 % CI: 0.75–3.51) in the two groups with vaccinated males versus 2.42 (95 % CI: 0.97–7.63) and 3.35 (95 % CI: 1.95–6.30) in the groups with unvaccinated males. Results were similar for the three HPV groups.

Conclusions

There was no consistent pattern of protection against incident HPV detection in females and no indication that recent vaccination was associated with lower transmission in discordant couples or with protection for one’s partner. Findings should not be generalized to younger populations.

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来源期刊

Journal of Clinical Virology 医学-病毒学

CiteScore

22.70

自引率

1.10%

发文量

149

审稿时长

24 days

期刊介绍： The Journal of Clinical Virology, an esteemed international publication, serves as the official journal for both the Pan American Society for Clinical Virology and The European Society for Clinical Virology. Dedicated to advancing the understanding of human virology in clinical settings, the Journal of Clinical Virology focuses on disseminating research papers and reviews pertaining to the clinical aspects of virology. Its scope encompasses articles discussing diagnostic methodologies and virus-induced clinical conditions, with an emphasis on practicality and relevance to clinical practice. The journal publishes on topics that include: • new diagnostic technologies • nucleic acid amplification and serologic testing • targeted and metagenomic next-generation sequencing • emerging pandemic viral threats • respiratory viruses • transplant viruses • chronic viral infections • cancer-associated viruses • gastrointestinal viruses • central nervous system viruses • one health (excludes animal health)