RNA纳米颗粒转染：比较RNA包封与吸附方法

IF 4 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Bioconjugate Chemistry Pub Date : 2025-02-25 DOI:10.1021/acs.bioconjchem.5c0002810.1021/acs.bioconjchem.5c00028

Amy E. Laturski, Maria T. Dulay, Jillian L. Perry and Joseph M. DeSimone*,

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引用次数: 0

摘要

从历史上看，通过纳米颗粒递送RNA主要依赖于封装，正如SARS-CoV-2疫苗中的脂质纳米颗粒所证明的那样。对纳米颗粒表面RNA降解的担忧最初限制了基于吸附的方法的探索。然而，最近的进展重新引起了人们对吸附作为可行替代方法的兴趣。本观点探讨了RNA在纳米颗粒中的掺入方法，比较了包封、吸附以及包封和吸附的结合，并提出了一个框架，指导根据一般特征选择最合适的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Transfection via RNA-Based Nanoparticles: Comparing Encapsulation vs Adsorption Approaches of RNA Incorporation

查看原文本刊更多论文

Transfection via RNA-Based Nanoparticles: Comparing Encapsulation vs Adsorption Approaches of RNA Incorporation

Historically, RNA delivery via nanoparticles has primarily relied on encapsulation, as demonstrated by lipid nanoparticles in SARS-CoV-2 vaccines. Concerns about RNA degradation on nanoparticle surfaces initially limited the exploration of adsorption-based approaches. However, recent advancements have renewed interest in adsorption as a viable alternative. This Viewpoint explores the approaches of RNA incorporation in nanoparticles, comparing encapsulation, adsorption, and the combination of encapsulation and adsorption, and presents a framework to guide the selection of the most suitable strategy based on general characteristics.

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来源期刊

Bioconjugate Chemistry 生物-化学综合

CiteScore

9.00

自引率

2.10%

发文量

236

审稿时长

1.4 months

期刊介绍： Bioconjugate Chemistry invites original contributions on all research at the interface between man-made and biological materials. The mission of the journal is to communicate to advances in fields including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presentation of research relevant to all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.