普瑞巴林与羧酸共晶:结构和热分析

IF 3.2 2区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Pablo E. Gaztañaga*, Eleonora Freire Espeleta and Daniel R. Vega, 
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引用次数: 0

摘要

制备了普瑞巴林(PGB)与不同羧酸的共晶,并用x射线单晶衍射测定了其晶体结构。得到的共晶结构均为等晶结构,与游离PGB晶体结构(PGB_AN)相关。这些结构的相似性导致了类似的热行为:在加热时,共晶分离,PGB_AN作为最终产物之一。值得注意的是,辛酸形成的共晶在加热时表现出多个单晶到单晶的相变。最初,1:1的化学计量样品在44°C时表现出不比例转变。结果表明,该单晶是一种新型的1:2化学计量的共晶。进一步加热引起偏析,最终生成PGB_AN单晶。在与癸酸的共晶中观察到类似的行为,但在1:2化学计量的共晶中观察到不同的结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Pregabalin Cocrystals with Carboxylic Acid: Structural and Thermal Analyses

Pregabalin Cocrystals with Carboxylic Acid: Structural and Thermal Analyses

Cocrystals of pregabalin (PGB) with different carboxylic acids were developed, and their crystal structures were determined by single crystal X-ray diffraction. All obtained cocrystal structures were isostructural and related to the free PGB crystal structure (PGB_AN). These structural similarities result in analogous thermal behavior: upon heating, cocrystals segregate, with PGB_AN as one of the final products. Notably, cocrystals formed with octanoic acid exhibited multiple single crystal to single crystal phase transitions upon heating. Initially, the 1:1 stoichiometric sample exhibited a disproportion transition at 44 °C. As a result, the single crystal is a new cocrystal of 1:2 stoichiometry. Further heating induced segregation, ultimately yielding a PGB_AN single crystal. Similar behavior was observed in cocrystals with decanoic acid, but a different structure is observed in the 1:2 stoichiometry cocrystal.

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来源期刊
Crystal Growth & Design
Crystal Growth & Design 化学-材料科学:综合
CiteScore
6.30
自引率
10.50%
发文量
650
审稿时长
1.9 months
期刊介绍: The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials. Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.
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