失眠会加速老年人的表观遗传时钟

IF 5.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Nadia Alejandra Rivero-Segura, Julian Daniel Rodriguez Cuartas, Paola Garcia-delaTorre, Sergio Sanchez-Garcia, Ricardo Ramirez-Aldana, Juan Carlos Gomez-Verjan
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引用次数: 0

摘要

失眠是一种常见的睡眠障碍,主要表现为睡眠质量差和睡眠时间不足。它影响着全球很大一部分人口,并与认知能力下降、焦虑、慢性疲劳、注意力不集中和记忆障碍等身心后果相关。有趣的是,它还与衰老和与年龄相关的疾病(心血管、代谢和神经退行性疾病)有关。另一方面,随着年龄的增长,DNA甲基化模式会发生重大变化。这些已被用于开发所谓的表观遗传时钟,以估计与环境和疾病风险相关的生物年龄。很少有研究评估失眠和表观遗传时钟之间的关系,从而深入了解失眠在加速衰老中的作用。因此,在本研究中,我们利用Illumina EPICv进行了表观遗传分析。对63名老年人(>;研究失眠与表观遗传年龄(HorvathAGE、HannumAGE、PhenoAGE、SkinBloodClock、GrimAGE、DunedinPACE、DNAmTL)之间的关系。结果,我们发现失眠患者的GrimAGE和皮肤血液时钟之间的加速和相关性增加,DNAmTL显著减少。EWAS分析显示了低甲基化的全球模式和几种蛋白质停滞和氧化途径的富集。总之,我们的研究结果表明,失眠会增加GrimAGE和SkinBloodClock的加速,并可能参与端粒缩短。此外,失眠引起的DNA甲基化模式的变化会影响蛋白质平衡和氧化应激。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insomnia accelerates the epigenetic clocks in older adults

Insomnia is a common sleep disorder characterized mainly by poor sleep quality and insufficient sleep duration. It affects a significant proportion of the global population and is correlated with physical and mental consequences such as cognitive decline, anxiety, chronic fatigue, poor concentration, and memory impairment. Interestingly, it is also linked to ageing and age-related diseases (cardiovascular, metabolic, and neurodegenerative). On the other hand, as we age, DNA methylation patterns undergo significant changes. These have been used to develop the so-called epigenetic clocks that estimate the biological age linked to the environment and the risk of diseases. Few studies have evaluated the association between insomnia and epigenetic clocks, providing insight into the role of insomnia in ageing acceleration. Therefore, in the present study, we carried out an epigenetic analysis by using Illumina EPICv.2 array on 63 older adults (> 60 years old, n = 33 with insomnia vs. n = 30 control) to evaluate the relation between insomnia and epigenetic ages (HorvathAGE, HannumAGE, PhenoAGE, SkinBloodClock, GrimAGE, DunedinPACE, DNAmTL). As a result, we found an increased acceleration and correlation between GrimAGE and SkinBloodClock and a significant reduction in the DNAmTL in individuals with insomnia. An EWAS analysis showed a global pattern of hypomethylation and an enrichment of several proteostasis and oxidative pathways. In conclusion, our results suggest that insomnia increases GrimAGE and SkinBloodClock acceleration and may be participating in telomere shortening. Additionally, changes in DNA methylation patterns induced by insomnia impact proteostasis and oxidative stress.

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来源期刊
GeroScience
GeroScience Medicine-Complementary and Alternative Medicine
CiteScore
10.50
自引率
5.40%
发文量
182
期刊介绍: GeroScience is a bi-monthly, international, peer-reviewed journal that publishes articles related to research in the biology of aging and research on biomedical applications that impact aging. The scope of articles to be considered include evolutionary biology, biophysics, genetics, genomics, proteomics, molecular biology, cell biology, biochemistry, endocrinology, immunology, physiology, pharmacology, neuroscience, and psychology.
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