脂质在软骨润滑中的作用的最新研究进展

IF 6.3 1区 工程技术 Q1 ENGINEERING, MECHANICAL
Yumeng Xue, Xiaolian Niu, Jin Zhou, Lizhen Wang, Yubo Fan
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引用次数: 0

摘要

关节软骨(AC)润滑不足会引发AC的不可逆和进行性退化,称为骨关节炎(OA)。基于生物润滑的策略被认为是恢复OA延迟甚至OA愈合的临时软骨润滑的有效方法。润滑剂的设计激发了对软骨低摩擦背后的原因和软骨中负责润滑功能的成分的探索。近年来,脂类作为一种新兴的AC润滑成分被广泛研究并证实在维持软骨润滑中发挥着重要作用。本文从骨软骨组织的生理复杂性和微环境的角度,提出了制备具有良好润滑功能的关节软骨生物材料所面临的主要挑战。接下来,我们将全面讨论AC的润滑模型,包括AC的润滑机理、OA与脂类的关系、脂类润滑机理及应用、磷脂在润滑中的协同作用。我们特别强调了脂类及其衍生物在润滑中的优势和应用。最后,我们分析了脂基生物材料实现OA完美治疗的前景。这篇全面而有指导意义的综述可以为我们目前对脂质和润滑相关疾病的理解提供深刻的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent development in understanding the role of lipids in cartilage lubrication

Recent development in understanding the role of lipids in cartilage lubrication

Lubrication deficiency in articular cartilage (AC) triggers irreversible and progressive degradation of AC, termed osteoarthritis (OA). Bio-lubrication-based strategies have been proposed as effective ways to restore temporary cartilage lubrication for OA postponement or even OA healing. The design of lubricants has inspired an exploration of the reasons behind the low friction in cartilage and the components responsible for the lubrication function in cartilage. Recently, lipids, as emerging lubrication components in AC, have been extensively studied and confirmed to play essential roles in maintaining cartilage lubrication. This review brings forward the main challenges of establishing a satisfactory functional articular cartilage biomaterial with sufficient lubrication from the perspectives of the complexity of physiology and microenvironment of osteochondral tissue. Next, we comprehensively discuss lubrication models of AC, including the lubrication mechanism of AC, OA associated with lipids, lipid lubrication mechanism and application, and the synergistic effects of phospholipids in lubrication. In particular, we highlight the advantages and application of lipids and their derivatives in lubrication. Finally, we analyze the future prospects of lipid-based biomaterials to achieve the perfect treatment of OA. This comprehensive and instructive review can provide deep insights into our current understanding of lipids and lubrication-related diseases.

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来源期刊
Friction
Friction Engineering-Mechanical Engineering
CiteScore
12.90
自引率
13.20%
发文量
324
审稿时长
13 weeks
期刊介绍: Friction is a peer-reviewed international journal for the publication of theoretical and experimental research works related to the friction, lubrication and wear. Original, high quality research papers and review articles on all aspects of tribology are welcome, including, but are not limited to, a variety of topics, such as: Friction: Origin of friction, Friction theories, New phenomena of friction, Nano-friction, Ultra-low friction, Molecular friction, Ultra-high friction, Friction at high speed, Friction at high temperature or low temperature, Friction at solid/liquid interfaces, Bio-friction, Adhesion, etc. Lubrication: Superlubricity, Green lubricants, Nano-lubrication, Boundary lubrication, Thin film lubrication, Elastohydrodynamic lubrication, Mixed lubrication, New lubricants, New additives, Gas lubrication, Solid lubrication, etc. Wear: Wear materials, Wear mechanism, Wear models, Wear in severe conditions, Wear measurement, Wear monitoring, etc. Surface Engineering: Surface texturing, Molecular films, Surface coatings, Surface modification, Bionic surfaces, etc. Basic Sciences: Tribology system, Principles of tribology, Thermodynamics of tribo-systems, Micro-fluidics, Thermal stability of tribo-systems, etc. Friction is an open access journal. It is published quarterly by Tsinghua University Press and Springer, and sponsored by the State Key Laboratory of Tribology (TsinghuaUniversity) and the Tribology Institute of Chinese Mechanical Engineering Society.
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