巴洛昔韦改善小鼠鼻内或眼内感染甲型流感病毒h5n1污染的牛奶后的疾病结果

IF 20.5 1区生物学 Q1 MICROBIOLOGY

Nature Microbiology Pub Date : 2025-03-17 DOI:10.1038/s41564-025-01961-5

Jeremy C. Jones, Konstantin Andreev, Thomas P. Fabrizio, Andrew S. Bowman, Elena A. Govorkova, Richard J. Webby

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引用次数: 0

摘要

测试针对在家畜（包括奶牛）中传播的甲型H5N1流感病毒的已批准抗病毒药物，对公共卫生和大流行前规划至关重要。由于A（H5N1）疾病的严重程度，它不能在人身上进行测试。在小鼠中，我们证明了美国fda批准的巴洛韦治疗在甲型H5N1病毒污染的牛奶经鼻和眼致死性攻击后，比奥司他韦能改善疾病结果（生存和病毒传播）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow’s milk

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Baloxavir improves disease outcomes in mice after intranasal or ocular infection with Influenza A virus H5N1-contaminated cow’s milk

Testing approved antivirals against A(H5N1) influenza viruses circulating in peridomestic species, including dairy cows, is critical to public health and pre-pandemic planning. It cannot be tested in humans due to A(H5N1) disease severity. Here, in mice, we demonstrate that US FDA-approved baloxavir treatment mediates improved disease outcomes (survival and viral dissemination) over oseltamivir after lethal intranasal and ocular challenge with A(H5N1)-contaminated cow milk. The FDA-approved antiviral baloxavir improves disease outcomes in mice compared with oseltamivir after ocular and intranasal challenge with A(H5N1)-contaminated cow milk.

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来源期刊

Nature Microbiology Immunology and Microbiology-Microbiology

CiteScore

44.40

自引率

1.10%

发文量

226

期刊介绍： Nature Microbiology aims to cover a comprehensive range of topics related to microorganisms. This includes: Evolution: The journal is interested in exploring the evolutionary aspects of microorganisms. This may include research on their genetic diversity, adaptation, and speciation over time. Physiology and cell biology: Nature Microbiology seeks to understand the functions and characteristics of microorganisms at the cellular and physiological levels. This may involve studying their metabolism, growth patterns, and cellular processes. Interactions: The journal focuses on the interactions microorganisms have with each other, as well as their interactions with hosts or the environment. This encompasses investigations into microbial communities, symbiotic relationships, and microbial responses to different environments. Societal significance: Nature Microbiology recognizes the societal impact of microorganisms and welcomes studies that explore their practical applications. This may include research on microbial diseases, biotechnology, or environmental remediation. In summary, Nature Microbiology is interested in research related to the evolution, physiology and cell biology of microorganisms, their interactions, and their societal relevance.