以网络药理学和体外实验为基础，探讨红枣苷A对胶质瘤细胞增殖和迁移能力的影响。

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-03-14 DOI:10.1016/j.brainres.2025.149570

Quanzhou Lv , Lin Chen , Yuan Du , Peng Yang , Quanying Chen , Fayu Qin , Hongxia Zhang , Yan Li

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引用次数: 0

摘要

目的：预测并验证枣红苷A （JuA）对胶质瘤细胞增殖和迁移能力的影响，为胶质瘤的治疗开发新疗法。方法：采用化学信息学方法对复方黄芪多糖的药性进行测定。应用网络药理学分析了JuA抗胶质瘤的共同靶点、生物学功能和代谢途径。通过分子对接验证了JuA抗胶质瘤的核心靶点。体外实验验证了JuA的生物学功能。结果：化学信息学结果表明JuA有可能成为一种药物。网络药理学揭示了JuA和胶质瘤之间的294个共同靶点，这些靶点与增殖、迁移和多种信号通路有关。通过分子对接共验证了16个与信号通路相关的核心靶点。体外实验表明，JuA能抑制细胞增殖和迁移，减少细胞数量，改变细胞形态。结论：网络药理学和体外实验结果表明，JuA对胶质瘤细胞具有明显的毒性作用，可以通过抑制胶质瘤细胞的增殖和迁移来起到治疗胶质瘤的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Network pharmacology and in vitro experiments based strategy to explore the effects of Jujuboside A on the proliferation and migration ability of glioma cells

查看原文本刊更多论文

Network pharmacology and in vitro experiments based strategy to explore the effects of Jujuboside A on the proliferation and migration ability of glioma cells

Objective

This study predicted and verified the effects of Jujuboside A (JuA) on the proliferation and migration ability of glioma cells to developing new therapies for glioma treatment.

Methods

The druggability of JuA was determined by using cheminformatics. Network pharmacology was used to analyse common targets, biological function and metabolic pathways of JuA against glioma. The core targets of JuA against glioma were validated by using molecular docking. The biological functions of JuA were verified by in vitro experiments.

Results

Cheminformatics results showed that JuA is possible to be a drug. Network pharmacology revealed 294 shared targets between JuA and glioma, which were associated with proliferation, migration, and multiple signalling pathways. A total of 16 core targets related to the signalling pathways were verified by molecular docking. The in vitro experiments showed that JuA could inhibit cell proliferation and migration, decrease cell numbers and alter cell morphology.

Conclusion

The results of network pharmacology and in vitro experiments indicate that JuA has significant toxic effects on glioma cells, and can play a therapeutic role in treating glioma by inhibiting the proliferation and migration of glioma cells.

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.