COVID-19 患者与非 COVID-19 志愿者之间的定量脑容量差异：系统回顾

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-03-14 DOI:10.1016/j.neuroimage.2025.121146

Breanna K. Nelson , Lea N. Farah , Sidney A. Saint , Catie Song , Thalia S. Field , Vesna Sossi , A. Jon Stoessl , Cheryl Wellington , William G. Honer , Donna Lang , Noah D. Silverberg , William J. Panenka

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引用次数: 0

摘要

背景：大多数COVID-19神经影像学文献集中在感染后的急性期和临床明显病变。COVID-19对大脑结构的慢性影响尚不清楚。关于COVID-19感染后脑容量的差异，现有的结构神经影像学研究存在不一致。因此，我们的目的是系统地评估结构神经影像学文献，重点关注COVID-19患者和未感染COVID-19的志愿者在感染后超过6周的体积差异。方法：于2023年5月检索PubMed、Embase和Scopus，并于2024年9月更新检索，对COVID-19患者和非COVID-19志愿者在COVID-19后6周以上获得的MRI进行脑容量定量比较的研究。排除标准包括根据存在特定症状、病例报告和病例研究以及尸检研究选择的COVID-19患者。分别进行了前后引文追踪。结果：16项研究符合纳入标准。大多数研究报告称，与健康志愿者相比，COVID-19患者的灰质体积更小。然而，研究结果并不一致，有3项研究报告称，COVID-19组的灰质体积更大。此外，与专注于在家康复的患者的研究相比，以入院或ICU为特征的症状更严重的COVID-19队列研究更有可能报告的灰质体积小于健康志愿者。结论：系统文献综述表明，COVID-19疾病严重程度可能解释了COVID-19患者与健康志愿者脑容量差异的一些异质性。需要更多的纵向随访研究来评估COVID-19对脑容量影响的纵向过程。

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Quantitative brain volume differences between COVID-19 patients and non-COVID-19 volunteers: A systematic review

Background

The majority of COVID-19 neuroimaging literature focuses on the acute period after infection and clinically evident lesions. The chronic effects of COVID-19 on brain structure are less well defined. There are inconsistencies in the existing structural neuroimaging studies regarding differences in brain volumes after COVID-19 infection. It was thus our aim to systematically evaluate the structural neuroimaging literature focusing on volumetric differences between patients with COVID-19, and volunteers without COVID-19, at greater than 6 weeks post-infection.

Methods

PubMed, Embase, and Scopus were searched in May 2023 with an updated search in September 2024, for studies with a quantitative comparison of brain volumes between COVID-19 patients and non-COVID-19 volunteers with MRI acquired more than 6-weeks after COVID-19. Exclusion criteria included COVID-19 patients selected for the presence of specific symptoms, case reports and case studies, and post-mortem studies. Forwards and backwards citation chasing were performed.

Results

Sixteen studies met inclusion criteria. The majority of studies reported smaller grey matter volumes amongst COVID-19 patients compared to healthy volunteers. However, there were inconsistent findings, with 3 studies reporting larger grey matter volumes in the COVID-19 groups. Additionally, studies with COVID-19 cohorts with more severe presentations, characterized by admission to the hospital or the ICU, were more likely to report smaller grey matter volumes compared to healthy volunteers, than studies that were focused on patients who recovered at home.

Conclusion

A systematic review of the literature indicates that COVID-19 illness severity may explain some of the heterogeneity in brain volume differences between COVID-19 patients and healthy volunteers. More longitudinal follow-up studies are needed to assess the longitudinal course of COVID-19′s effects on brain volumes.

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.