利用多孔微凝胶设计颗粒状水凝胶支架的分层孔隙率，以改善细胞招募和组织整合（Adv.）

IF 18.5 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Functional Materials Pub Date : 2025-03-18 DOI:10.1002/adfm.202570070

Alexander Kedzierski, Sina Kheirabadi, Arian Jaberi, Zaman Ataie, Catherine L. Mojazza, Marisa L. Williamson, Anton M. Hjaltason, Aneesh Risbud, Yuanhui Xiang, Amir Sheikhi

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引用次数: 0

摘要

水凝胶支架在文章编号 2417704 中，Amir Sheikhi 及其合作者通过制造和共价组装明胶甲基丙烯酰（GelMA）多孔微凝胶，开发出一类具有分层多孔性的新型颗粒状水凝胶支架。与无孔微凝胶相比，这些支架具有更高的空隙率，从而提高了细胞招募和组织整合能力。这项研究可能会为开发分层多孔转化颗粒生物材料铺平道路，从而加速内源性组织修复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration (Adv. Funct. Mater. 12/2025)

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Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration (Adv. Funct. Mater. 12/2025)

Hydrogel Scaffolds

In article number 2417704, Amir Sheikhi and co-workers develop a new class of granular hydrogel scaffolds with hierarchical porosity by fabricating and covalently assembling gelatin methacryloyl (GelMA) porous microgels. These scaffolds feature a significantly higher void fraction compared with those made from nonporous microgels, thereby enhancing cell recruitment and tissue integration. This research may pave the way for developing hierarchically porous translational granular biomaterials, aiming to accelerate endogenous tissue repair.

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来源期刊

Advanced Functional Materials 工程技术-材料科学：综合

CiteScore

29.50

自引率

4.20%

发文量

2086

审稿时长

2.1 months

期刊介绍： Firmly established as a top-tier materials science journal, Advanced Functional Materials reports breakthrough research in all aspects of materials science, including nanotechnology, chemistry, physics, and biology every week. Advanced Functional Materials is known for its rapid and fair peer review, quality content, and high impact, making it the first choice of the international materials science community.