Aptamer-Directed Bidirectional Modulation of Vascular Niches for Promoted Regeneration of Segmental Trachea Defect (Adv. Funct. Mater. 12/2025)
Tissue-Specific Aptamer Matrices
In article number 2409071, Dong Xie, Deping Zhao, Yong Hu, Chang Chen, and co-workers successfully engineer a biomimetic trachea with regenerated vascular connective tissue scattered between avascular cartilage rings using the assembly of two distinct tissue-specific aptamer matrices. This approach fosters the development of (a)vascular niches in reconstructed trachea after end-to-end anastomosis, along with optimal structural, mechanical, and physiological features.
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