固定化方法对DNA拉伸特性的影响

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2025-03-17 DOI:10.1134/S0006350924701070

M. A. Didin

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引用次数: 0

摘要

研究了在固定力作用下具有一定末端条件的柔性聚合物分子的拉伸问题。建立了描述聚合物弹性的各种能量函数和各种固定方法的数学模型。结果表明，拉伸强度与聚合物的长度呈线性关系。给出了数值计算结果。所得结果为改进聚合物拉伸实验数据的分析提供了可能。该理论提供了几个可验证的预测，包括提高测量精度的实验方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The Effect of Immobilization Method on DNA Stretching Characteristics

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The Effect of Immobilization Method on DNA Stretching Characteristics

The problem of stretching a flexible polymer molecule with specified conditions at the ends under the action of a fixed force is considered. A mathematical model has been constructed for various energy functions describing the elasticity of the polymer and various immobilization methods. It is shown that the dependence of stretching on the length of the polymer is linear. The results of numerical calculations are presented. The results obtained make it possible to improve the analysis of experimental data on polymer stretching. The theory provides several verifiable predictions, including experimental methods that improve the accuracy of measurements.

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.