白藜芦醇对过氧化氢和紫外光修饰的人淋巴细胞的细胞保护和抗氧化作用

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2025-03-17 DOI:10.1134/S0006350924701100

M. A. Nakvasina, V. G. Artyukhov, E. N. Chursanova, O. V. Myachina, E. I. Korpusova, A. Yu. Deenkova, V. A. Shestykh

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引用次数: 0

摘要

在含有白藜芦醇（10 - 7,10 - 6,10 - 5 mol/L）的过氧化氢（10-5 mol/L）照射下（254 nm, 1510 J/m2），人外周血淋巴细胞的凋亡和坏死过程强度降低。结果表明，白藜芦醇对淋巴细胞的细胞保护作用是由于降低细胞内活性氧和钙离子的生成水平，增加抗氧化酶（过氧化氢酶和谷胱甘肽还原酶）的活性，增加质膜的过氧化物抗性以及与DNA的相互作用。讨论了白藜芦醇作为过氧化氢和紫外线辐射诱导淋巴细胞凋亡和坏死死亡过程的调节剂的可能作用机制。

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The Cytoprotective and Antioxidant Effects of Resveratrol on Human Lymphocytes Modified with Hydrogen Peroxide and UV Light

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The Cytoprotective and Antioxidant Effects of Resveratrol on Human Lymphocytes Modified with Hydrogen Peroxide and UV Light

A decrease in the intensity of the processes of apoptotic and necrotic death of human peripheral blood lymphocytes was found after exposure to UV light (254 nm, 1510 J/m²) and hydrogen peroxide (10^–5 mol/L) in the presence of resveratrol (10^–7, 10^–6, 10^–5 mol/L). It was revealed that the cytoprotective effect of resveratrol on lymphocytes is due to a decrease in the level of production of intracellular reactive oxygen species and calcium ions, an increase in the activity of antioxidant enzymes, that is, catalase and glutathione reductase, an increase in peroxide resistance of plasma membranes, and interaction with DNA. Possible mechanisms of action of resveratrol as a regulator of the processes of apoptotic and necrotic death of lymphocytes induced by exposure to hydrogen peroxide and UV radiation are discussed.

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.