{"title":"新的希夫碱棒状苯并噻唑衍生物:设计、合成、生物学评价、分子对接和药物动力学研究作为抗菌和抗真菌药物","authors":"Rahul Tailor, Jigisha Modi, Savan Patel, Rucha Wani, Merwyn Dcosta, Arvind Singh","doi":"10.1134/S1070427224603188","DOIUrl":null,"url":null,"abstract":"<p>A series of <i>N,N'</i>-(methylenebis(4-methyl-7-nitrobenzo[<i>d</i>]thiazole-6,2-diyl))bis(1-arylmeth- animine) derivatives <b>3a–3o</b> were synthesized by the reaction of 6,6'-methylene bis(2-amino-4-methyl-7-nitrobenzo[<i>d</i>]thiazole) with different aromatic aldehyde. All the synthesized compounds were characterized by spectroscopic analysis such as FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, mass spectra and elemental analysis. The antibacterial activity of these compounds was first studied <i>in vitro</i> by the disk diffusion assay against gram positive and gram negative bacteria. The minimum inhibition concentration (MIC) was then determined with the references of standard drug Ampicillin and Chloramphenicol. The antifungal activity was examined against <i>Candida albicans, Aspergillus clavatus</i>, and <i>Aspergillus niger</i> by the serial plate dilution method using Nystatin and Griseofulv in as standard. All fifteen derivatives were docked against the two proteins, namely carbonic anhydrase 2 (PDB ID: 7SEV) and lanosterol 14 alpha demethylase ((PDB ID: 5V5Z).The compound <b>3m</b> has shown the best binding score against carbonic anhydrase 2 (PDB ID: 7SEV) (–9.785 kcal/mol) and compound <b>3o</b> has shown the best score for fungal lanosterol 14 alpha demethylase (–12.538 kcal/mol). The physicochemical properties of potent derivatives were also reported.</p>","PeriodicalId":757,"journal":{"name":"Russian Journal of Applied Chemistry","volume":"97 10","pages":"790 - 799"},"PeriodicalIF":0.6000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New Schiff Base Clubbed Benzothiazole Derivatives: Design, Synthesis, Biological Evaluation, Molecular Docking and Pharmacokinetic Studies as Antibacterial and Antifungal Agents\",\"authors\":\"Rahul Tailor, Jigisha Modi, Savan Patel, Rucha Wani, Merwyn Dcosta, Arvind Singh\",\"doi\":\"10.1134/S1070427224603188\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A series of <i>N,N'</i>-(methylenebis(4-methyl-7-nitrobenzo[<i>d</i>]thiazole-6,2-diyl))bis(1-arylmeth- animine) derivatives <b>3a–3o</b> were synthesized by the reaction of 6,6'-methylene bis(2-amino-4-methyl-7-nitrobenzo[<i>d</i>]thiazole) with different aromatic aldehyde. All the synthesized compounds were characterized by spectroscopic analysis such as FTIR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, mass spectra and elemental analysis. The antibacterial activity of these compounds was first studied <i>in vitro</i> by the disk diffusion assay against gram positive and gram negative bacteria. The minimum inhibition concentration (MIC) was then determined with the references of standard drug Ampicillin and Chloramphenicol. The antifungal activity was examined against <i>Candida albicans, Aspergillus clavatus</i>, and <i>Aspergillus niger</i> by the serial plate dilution method using Nystatin and Griseofulv in as standard. All fifteen derivatives were docked against the two proteins, namely carbonic anhydrase 2 (PDB ID: 7SEV) and lanosterol 14 alpha demethylase ((PDB ID: 5V5Z).The compound <b>3m</b> has shown the best binding score against carbonic anhydrase 2 (PDB ID: 7SEV) (–9.785 kcal/mol) and compound <b>3o</b> has shown the best score for fungal lanosterol 14 alpha demethylase (–12.538 kcal/mol). The physicochemical properties of potent derivatives were also reported.</p>\",\"PeriodicalId\":757,\"journal\":{\"name\":\"Russian Journal of Applied Chemistry\",\"volume\":\"97 10\",\"pages\":\"790 - 799\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-03-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of Applied Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070427224603188\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Applied Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070427224603188","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
New Schiff Base Clubbed Benzothiazole Derivatives: Design, Synthesis, Biological Evaluation, Molecular Docking and Pharmacokinetic Studies as Antibacterial and Antifungal Agents
A series of N,N'-(methylenebis(4-methyl-7-nitrobenzo[d]thiazole-6,2-diyl))bis(1-arylmeth- animine) derivatives 3a–3o were synthesized by the reaction of 6,6'-methylene bis(2-amino-4-methyl-7-nitrobenzo[d]thiazole) with different aromatic aldehyde. All the synthesized compounds were characterized by spectroscopic analysis such as FTIR, 1H NMR, 13C NMR, mass spectra and elemental analysis. The antibacterial activity of these compounds was first studied in vitro by the disk diffusion assay against gram positive and gram negative bacteria. The minimum inhibition concentration (MIC) was then determined with the references of standard drug Ampicillin and Chloramphenicol. The antifungal activity was examined against Candida albicans, Aspergillus clavatus, and Aspergillus niger by the serial plate dilution method using Nystatin and Griseofulv in as standard. All fifteen derivatives were docked against the two proteins, namely carbonic anhydrase 2 (PDB ID: 7SEV) and lanosterol 14 alpha demethylase ((PDB ID: 5V5Z).The compound 3m has shown the best binding score against carbonic anhydrase 2 (PDB ID: 7SEV) (–9.785 kcal/mol) and compound 3o has shown the best score for fungal lanosterol 14 alpha demethylase (–12.538 kcal/mol). The physicochemical properties of potent derivatives were also reported.
期刊介绍:
Russian Journal of Applied Chemistry (Zhurnal prikladnoi khimii) was founded in 1928. It covers all application problems of modern chemistry, including the structure of inorganic and organic compounds, kinetics and mechanisms of chemical reactions, problems of chemical processes and apparatus, borderline problems of chemistry, and applied research.