定制兽医双释放片剂的3D打印:甲氧氯普胺†的半固体挤出方法

Rathna Mathiyalagan, Max Westerlund, Alaa Mahran, Rabia Altunay, Jarkko Suuronen, Mirja Palo, Johan O. Nyman, Eero Immonen, Jessica M. Rosenholm, Erica Monaco and Xiaoju Wang
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引用次数: 0

摘要

甲氧氯普胺(MCP)常用于控制动物的恶心和呕吐,但由于半衰期短,需要每天服用三次。此外,商业兽药MCP配方目前缺乏。因此,兽医从业人员经常求助于说明书外使用人类药物,这可能导致患者结果不一致,并因剂量不足引起并发症。因此,在兽医实践中,越来越多的人认识到需要个性化的治疗策略,因为它们可以为动物患者提供量身定制的剂量和改进的选择。为了解决这一未满足的需求并克服这些挑战,我们的研究重点是利用半固体挤压(SSE) 3D打印为不同大小的猫和狗开发每日一次的双释放定制剂量。含有不同纤维素聚合物的双释放系统旨在提供快速起效和持续作用,以确保延长药物释放时间并尽量减少给药频率。所制备的油墨配方成功地用于获得不同尺寸的定制剂量,设计与获得的药物量之间具有显著的相关性。溶出度研究揭示了聚合物组合和片剂表面积对药物释放的影响。动力学模拟表明,扩散和侵蚀都参与了其释放机制。这项研究强调了SSE 3D打印在开发双释放给药系统中的实际应用,通过生产精确和宠物友好的定制片剂来提高兽医治疗接近护理点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

3D printing of tailored veterinary dual-release tablets: a semi-solid extrusion approach for metoclopramide†

3D printing of tailored veterinary dual-release tablets: a semi-solid extrusion approach for metoclopramide†

Metoclopramide (MCP) is frequently used to control nausea and vomiting in animals, but its short half-life requires it to be administered thrice daily. In addition, commercial veterinary MCP formulations are currently lacking. As a result, veterinary practitioners often resort to off-label use of human medications, which can lead to inconsistent patient outcomes and complications arising from inadequate dosing. Thus, there is a growing recognized need for individualized treatment strategies also within veterinary practice, as they can offer tailored doses and improved options for animal patients. To address this unmet need and overcome these challenges, our study focused on developing a once-daily dual-release tailored dose for different-sized cats and dogs utilizing semi-solid extrusion (SSE) 3D printing. The dual-release system containing different cellulosic polymers is designed to provide a rapid onset and sustained action to ensure prolonged drug release and minimize the frequency of administration. The produced printing ink formulations were successfully used to obtain different-sized tailored doses with a significant correlation between the designs and the obtained drug amounts. Dissolution studies revealed the impact of polymer combinations and tablet surface area on drug release profiles. Kinetic modeling indicated that both diffusion and erosion are involved in the release mechanisms. This research emphasizes the practical use of SSE 3D printing in developing dual-release delivery systems by producing precise and pet-friendly tailored tablets to enhance veterinary treatments close to the point-of-care.

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