精神分裂症个体形态变形的空间模式：未受影响的兄弟姐妹的皮质假定代偿性

IF 5.3 2区医学 Q1 CLINICAL NEUROLOGY

Progress in Neuro-Psychopharmacology & Biological Psychiatry Pub Date : 2025-03-14 DOI:10.1016/j.pnpbp.2025.111329

Pan Yunzhi , Zhong Mingjun , Chen Yuqing , Han Lin , Huang Weiqing , Tan Wenjian , Huang Danqing , Yang Jun , Cheng Yixing , Chen Xudong

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Spatial patterns of individual morphological deformation in schizophrenia: Putative cortical compensatory of unaffected sibling

Background

Neuroimaging advancements have revealed morphological deformation across various indicators, illuminating the neuropathological origins of schizophrenia. However, consolidating the findings across indicators and assessing regional global deformation at individual-level poses a significant challenge.

Methods

We propose individual morphological deformation index (IMDI) as potential biomarker for schizophrenia leveraging a distance algorithm that incorporates three key indicators (cortical thickness, gyrification, and volume), and applied it for 199 schizophrenia patients, 218 healthy controls, and 47 unaffected siblings. Additionally, we studied the relationships between polygenic risks, symptomology, cognition, social functioning and regional IMDI.

Results

Our findings reveal significantly higher IMDI in specific brain regions (bilateral pars opercularis, lateral orbitofrontal, left superior parietal, right pars orbitalis, and superior temporal) in patients, demonstrating two distinct spatial patterns linked to either isolated indicator reduction or concurrent declines across multiple indicators. Notably, unaffected siblings exhibited higher IMDI than controls, primarily due to cortical volume expansion in the right pars opercularis and superior temporal regions. Patients with higher IMDI had more severe positive symptoms, impaired cognition, reduced social functioning and selfcare ability. Participants with higher polygenic scores showed higher IMDI specifically in left caudal middle frontal regions.

Conclusions

The proposed IMDI biomarker offers an objective, interpretable way to quantify global regional deformation and integrate disparate neuroimaging indicators. Our results indicate that schizophrenia-related cortical deformations encompass sensorimotor, attention, default mode, and frontoparietal networks, exhibiting at least two spatial patterns. Moreover, siblings may exhibit compensation in cortical volume. These insights offer a novel perspective on the neuroanatomical underpinnings of schizophrenia.

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来源期刊

Progress in Neuro-Psychopharmacology & Biological Psychiatry 医学-精神病学

CiteScore

12.00

自引率

1.80%

发文量

153

审稿时长

56 days

期刊介绍： Progress in Neuro-Psychopharmacology & Biological Psychiatry is an international and multidisciplinary journal which aims to ensure the rapid publication of authoritative reviews and research papers dealing with experimental and clinical aspects of neuro-psychopharmacology and biological psychiatry. Issues of the journal are regularly devoted wholly in or in part to a topical subject. Progress in Neuro-Psychopharmacology & Biological Psychiatry does not publish work on the actions of biological extracts unless the pharmacological active molecular substrate and/or specific receptor binding properties of the extract compounds are elucidated.