恐惧在癫痫的神经精神方面：杏仁核的作用是什么？

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurophysiologie Clinique/Clinical Neurophysiology Pub Date : 2025-03-17 DOI:10.1016/j.neucli.2025.103062

Alexis Tarrada , Yassine Jamal Eddine

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引用次数: 0

摘要

恐惧是生存之本；然而，它的失调可能导致各种神经精神疾病。了解与恐惧表达有关的神经网络有助于制定治疗干预措施（药理学或心理教育）。我们的目的是总结杏仁核的可疑作用，以及其他结构，如脑岛、额叶和颞叶联合皮层和脑干。可以区分出导致恐惧表达的三种途径：间接的、直接的和内感受的，由杏仁核组成的“恐惧中枢”。此外，颞叶癫痫暗示恐惧是一种“自发”症状，这可能为理解恐惧的生理机制提供了一个有趣的模型。

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Fear in the neuropsychiatric aspects of epilepsy: What role for the amygdala?

Fear is essential for survival; however, its dysregulation may lead to various neuropsychiatric disorders. Understanding the neural networks involved in the expression of fear is useful for elaborating therapeutic interventions (pharmacological or psychoeducation). We aimed to summarize suspected roles of amygdala, but also of other structures such as insula, frontal and temporal associative cortices, and brainstem. Three pathways can be distinguished leading to the expression of fear: indirect, direct and interoceptive, comprising the amygdala as a “hub of fear”. Moreover, temporal epilepsies that imply fear as a “spontaneous” symptom may constitute an interesting model for understanding physiological mechanisms of fear.

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来源期刊

Neurophysiologie Clinique/Clinical Neurophysiology 医学-临床神经学

CiteScore

5.20

自引率

3.30%

发文量

审稿时长

60 days

期刊介绍： Neurophysiologie Clinique / Clinical Neurophysiology (NCCN) is the official organ of the French Society of Clinical Neurophysiology (SNCLF). This journal is published 6 times a year, and is aimed at an international readership, with articles written in English. These can take the form of original research papers, comprehensive review articles, viewpoints, short communications, technical notes, editorials or letters to the Editor. The theme is the neurophysiological investigation of central or peripheral nervous system or muscle in healthy humans or patients. The journal focuses on key areas of clinical neurophysiology: electro- or magneto-encephalography, evoked potentials of all modalities, electroneuromyography, sleep, pain, posture, balance, motor control, autonomic nervous system, cognition, invasive and non-invasive neuromodulation, signal processing, bio-engineering, functional imaging.