药物治疗和步态冻结对帕金森病患者安静站立时乱走和颤抖的影响。

IF 0.9 4区 医学 Q4 NEUROSCIENCES
Motor Control Pub Date : 2025-03-14 Print Date: 2025-04-01 DOI:10.1123/mc.2024-0063
Layla Cupertino, Felipe Marrese Bersotti, Thayna Magalhães Novaes, Luis Mochizuki, Solaiman Shokur, Mohamed Bouri, Fabio Augusto Barbieri, Daniel Boari Coelho
{"title":"药物治疗和步态冻结对帕金森病患者安静站立时乱走和颤抖的影响。","authors":"Layla Cupertino, Felipe Marrese Bersotti, Thayna Magalhães Novaes, Luis Mochizuki, Solaiman Shokur, Mohamed Bouri, Fabio Augusto Barbieri, Daniel Boari Coelho","doi":"10.1123/mc.2024-0063","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Individuals with Parkinson's disease (PD) with freezing of gait (FoG) exhibit difficulty with changes in sensory input, indicating a potential sensorimotor integration deficit. Understanding how levodopa impacts balance particularly in FoG, is critical. As traditional postural sway measures may not fully capture the complexity of balance control, rambling and trembling decomposition of the center of pressure allows a more detailed assessment of postural control by distinguishing between supraspinal and spinal contributions, offering insights into sensorimotor integration deficits. This study aims to analyze the effects of medication and FoG on rambling and trembling in quiet standing in individuals with PD.</p><p><strong>Methods: </strong>We analyzed 13 individuals with PD with FoG (PD freezers) and 19 individuals with PD without FoG (PD nonfreezers) while quiet standing on a rigid and malleable surface under (ON) and without (OFF) dopaminergic medication. Area, root mean square, and mean velocity were calculated for rambling and trembling trajectory.</p><p><strong>Results: </strong>For the rambling, all variables were significantly higher on the malleable compared with the rigid surface. For trembling, (a) all variables were higher on the malleable compared with the rigid surface (p < .001), and (b) area and medial-lateral root mean square were significantly higher ON compared with OFF medication for both groups of participants similarly.</p><p><strong>Conclusion: </strong>Our results strengthen the evidence that PD freezers have the same postural sway in quiet posture as PD nonfreezers, using similar mechanisms to control the posture. In addition, levodopa influences spinal mechanisms more than supraspinal ones in individuals with PD in quiet standing.</p>","PeriodicalId":49795,"journal":{"name":"Motor Control","volume":" ","pages":"202-214"},"PeriodicalIF":0.9000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Medication and Freezing of Gait on Rambling and Trembling in Quiet Standing in Individuals With Parkinson's Disease.\",\"authors\":\"Layla Cupertino, Felipe Marrese Bersotti, Thayna Magalhães Novaes, Luis Mochizuki, Solaiman Shokur, Mohamed Bouri, Fabio Augusto Barbieri, Daniel Boari Coelho\",\"doi\":\"10.1123/mc.2024-0063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Individuals with Parkinson's disease (PD) with freezing of gait (FoG) exhibit difficulty with changes in sensory input, indicating a potential sensorimotor integration deficit. Understanding how levodopa impacts balance particularly in FoG, is critical. As traditional postural sway measures may not fully capture the complexity of balance control, rambling and trembling decomposition of the center of pressure allows a more detailed assessment of postural control by distinguishing between supraspinal and spinal contributions, offering insights into sensorimotor integration deficits. This study aims to analyze the effects of medication and FoG on rambling and trembling in quiet standing in individuals with PD.</p><p><strong>Methods: </strong>We analyzed 13 individuals with PD with FoG (PD freezers) and 19 individuals with PD without FoG (PD nonfreezers) while quiet standing on a rigid and malleable surface under (ON) and without (OFF) dopaminergic medication. Area, root mean square, and mean velocity were calculated for rambling and trembling trajectory.</p><p><strong>Results: </strong>For the rambling, all variables were significantly higher on the malleable compared with the rigid surface. For trembling, (a) all variables were higher on the malleable compared with the rigid surface (p < .001), and (b) area and medial-lateral root mean square were significantly higher ON compared with OFF medication for both groups of participants similarly.</p><p><strong>Conclusion: </strong>Our results strengthen the evidence that PD freezers have the same postural sway in quiet posture as PD nonfreezers, using similar mechanisms to control the posture. In addition, levodopa influences spinal mechanisms more than supraspinal ones in individuals with PD in quiet standing.</p>\",\"PeriodicalId\":49795,\"journal\":{\"name\":\"Motor Control\",\"volume\":\" \",\"pages\":\"202-214\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-03-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Motor Control\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1123/mc.2024-0063\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Motor Control","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1123/mc.2024-0063","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"Print","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

背景:伴有步态冻结(FoG)的帕金森病(PD)患者表现出感觉输入改变困难,表明潜在的感觉运动整合缺陷。了解左旋多巴是如何影响平衡的,尤其是在FoG中,是至关重要的。由于传统的姿势摇摆测量方法可能无法完全捕捉平衡控制的复杂性,压力中心的散乱和颤抖分解可以通过区分棘上和脊柱的作用来更详细地评估姿势控制,从而提供对感觉运动整合缺陷的见解。本研究旨在分析药物和FoG对PD患者安静站立时散漫和颤抖的影响。方法:我们分析了13例有FoG (PD冰柜)的PD患者和19例无FoG (PD非冰柜)的PD患者,在(on)和(OFF)多巴胺能药物下安静地站在刚性和可塑表面上。计算了漫散和抖动轨迹的面积、均方根和平均速度。结果:对于漫游者,可塑表面的各项指标均明显高于刚性表面。对于颤抖,(a)与刚性表面相比,可塑表面上的所有变量都更高(p < 0.001), (b)两组参与者的面积和内侧-外侧均方根显著高于关闭药物治疗。结论:我们的研究结果加强了PD冷冻机与PD非冷冻机在安静姿势下具有相同的姿势摇摆的证据,使用相似的机制来控制姿势。此外,左旋多巴对PD患者脊柱机制的影响大于对脊柱上机制的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Medication and Freezing of Gait on Rambling and Trembling in Quiet Standing in Individuals With Parkinson's Disease.

Background: Individuals with Parkinson's disease (PD) with freezing of gait (FoG) exhibit difficulty with changes in sensory input, indicating a potential sensorimotor integration deficit. Understanding how levodopa impacts balance particularly in FoG, is critical. As traditional postural sway measures may not fully capture the complexity of balance control, rambling and trembling decomposition of the center of pressure allows a more detailed assessment of postural control by distinguishing between supraspinal and spinal contributions, offering insights into sensorimotor integration deficits. This study aims to analyze the effects of medication and FoG on rambling and trembling in quiet standing in individuals with PD.

Methods: We analyzed 13 individuals with PD with FoG (PD freezers) and 19 individuals with PD without FoG (PD nonfreezers) while quiet standing on a rigid and malleable surface under (ON) and without (OFF) dopaminergic medication. Area, root mean square, and mean velocity were calculated for rambling and trembling trajectory.

Results: For the rambling, all variables were significantly higher on the malleable compared with the rigid surface. For trembling, (a) all variables were higher on the malleable compared with the rigid surface (p < .001), and (b) area and medial-lateral root mean square were significantly higher ON compared with OFF medication for both groups of participants similarly.

Conclusion: Our results strengthen the evidence that PD freezers have the same postural sway in quiet posture as PD nonfreezers, using similar mechanisms to control the posture. In addition, levodopa influences spinal mechanisms more than supraspinal ones in individuals with PD in quiet standing.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Motor Control
Motor Control 医学-神经科学
CiteScore
1.80
自引率
9.10%
发文量
48
审稿时长
>12 weeks
期刊介绍: Motor Control (MC), a peer-reviewed journal, provides a multidisciplinary examination of human movement across the lifespan. To keep you abreast of current developments in the field of motor control, it offers timely coverage of important topics, including issues related to motor disorders. This international journal publishes many types of research papers, from clinical experimental to modeling and theoretical studies. These papers come from such varied disciplines as biomechanics, kinesiology, neurophysiology, neuroscience, psychology, physical medicine, and rehabilitation. Motor Control, the official journal of the International Society of Motor Control, is designed to provide a multidisciplinary forum for the exchange of scientific information on the control of human movement across the lifespan, including issues related to motor disorders. Motor Control encourages submission of papers from a variety of disciplines including, but not limited to, biomechanics, kinesiology, neurophysiology, neuroscience, psychology, physical medicine, and rehabilitation. This peer-reviewed journal publishes a wide variety of types of research papers including clinical experimental, modeling, and theoretical studies. To be considered for publication, papers should clearly demonstrate a contribution to the understanding of control of movement. In addition to publishing research papers, Motor Control publishes review articles, quick communications, commentaries, target articles, and book reviews. When warranted, an entire issue may be devoted to a specific topic within the area of motor control.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信