Jayne MacMahon, Mohammed Massumi, Trang T Duong, Rose H Garrett, Audrey Bell-Peter, Kristi Whitney, Jo-Anne Marcuz, Y Ingrid Goh, Rae S M Yeung, Brian M Feldman
{"title":"青少年皮肌炎患者干扰素反应基因评分与疾病活动度密切相关","authors":"Jayne MacMahon, Mohammed Massumi, Trang T Duong, Rose H Garrett, Audrey Bell-Peter, Kristi Whitney, Jo-Anne Marcuz, Y Ingrid Goh, Rae S M Yeung, Brian M Feldman","doi":"10.3899/jrheum.2024-0806","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Type 1 interferons (IFNs) have been identified as potentially important measures of disease activity in Juvenile Dermatomyositis (JDM). An Interferon Response Gene-score (IRG-score) has been defined using NanoString technology and appears to correlate with disease activity in cross-sectional samples of JDM patients. This study aimed to determine if there is evidence of a correlation between disease activity and IRG-score, in patients with JDM, both early in disease course and longitudinally.</p><p><strong>Methods: </strong>All patients attending JDM clinic in SickKids were approached to enrol in the Childhood Arthritis and Rheumatic Diseases (CARD) biobank. We identified patients with a diagnosis of JDM, enrolled between January 2015 and June 2022. NanoString IRG-score was calculated from extracted RNA. The Modified Disease Activity Score (mDAS) was calculated based on clinical data collected prospectively through SickKids JDM registry. Spearman's correlation was calculated using all enrolment visit samples, and linear mixed model regression was used for subjects with multiple samples.</p><p><strong>Results: </strong>43 subjects with 87 bio-samples were identified, including 18 treatment-naïve subjects. Spearman's correlation at the enrolment visit was strong (r<sub>s</sub> = 0.78) with similar results seen in the treatment-naïve cohort (r<sub>s</sub> = 0.63). This relationship persisted over time, with linear mixed modelling of the treatment-naïve cohort showing beta-coefficient for the IRG-Score of 0.004 with p-value <0.001.</p><p><strong>Conclusion: </strong>This study shows evidence of a significant correlation between IRG-score and disease activity, which is maintained over time. This highlights the potential for IRG-score to be an important biomarker in JDM.</p>","PeriodicalId":50064,"journal":{"name":"Journal of Rheumatology","volume":" ","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Interferon Response Gene Score in Juvenile Dermatomyositis Correlates Strongly with Disease Activity.\",\"authors\":\"Jayne MacMahon, Mohammed Massumi, Trang T Duong, Rose H Garrett, Audrey Bell-Peter, Kristi Whitney, Jo-Anne Marcuz, Y Ingrid Goh, Rae S M Yeung, Brian M Feldman\",\"doi\":\"10.3899/jrheum.2024-0806\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Type 1 interferons (IFNs) have been identified as potentially important measures of disease activity in Juvenile Dermatomyositis (JDM). An Interferon Response Gene-score (IRG-score) has been defined using NanoString technology and appears to correlate with disease activity in cross-sectional samples of JDM patients. This study aimed to determine if there is evidence of a correlation between disease activity and IRG-score, in patients with JDM, both early in disease course and longitudinally.</p><p><strong>Methods: </strong>All patients attending JDM clinic in SickKids were approached to enrol in the Childhood Arthritis and Rheumatic Diseases (CARD) biobank. We identified patients with a diagnosis of JDM, enrolled between January 2015 and June 2022. NanoString IRG-score was calculated from extracted RNA. The Modified Disease Activity Score (mDAS) was calculated based on clinical data collected prospectively through SickKids JDM registry. Spearman's correlation was calculated using all enrolment visit samples, and linear mixed model regression was used for subjects with multiple samples.</p><p><strong>Results: </strong>43 subjects with 87 bio-samples were identified, including 18 treatment-naïve subjects. Spearman's correlation at the enrolment visit was strong (r<sub>s</sub> = 0.78) with similar results seen in the treatment-naïve cohort (r<sub>s</sub> = 0.63). This relationship persisted over time, with linear mixed modelling of the treatment-naïve cohort showing beta-coefficient for the IRG-Score of 0.004 with p-value <0.001.</p><p><strong>Conclusion: </strong>This study shows evidence of a significant correlation between IRG-score and disease activity, which is maintained over time. This highlights the potential for IRG-score to be an important biomarker in JDM.</p>\",\"PeriodicalId\":50064,\"journal\":{\"name\":\"Journal of Rheumatology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Rheumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3899/jrheum.2024-0806\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3899/jrheum.2024-0806","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Interferon Response Gene Score in Juvenile Dermatomyositis Correlates Strongly with Disease Activity.
Objective: Type 1 interferons (IFNs) have been identified as potentially important measures of disease activity in Juvenile Dermatomyositis (JDM). An Interferon Response Gene-score (IRG-score) has been defined using NanoString technology and appears to correlate with disease activity in cross-sectional samples of JDM patients. This study aimed to determine if there is evidence of a correlation between disease activity and IRG-score, in patients with JDM, both early in disease course and longitudinally.
Methods: All patients attending JDM clinic in SickKids were approached to enrol in the Childhood Arthritis and Rheumatic Diseases (CARD) biobank. We identified patients with a diagnosis of JDM, enrolled between January 2015 and June 2022. NanoString IRG-score was calculated from extracted RNA. The Modified Disease Activity Score (mDAS) was calculated based on clinical data collected prospectively through SickKids JDM registry. Spearman's correlation was calculated using all enrolment visit samples, and linear mixed model regression was used for subjects with multiple samples.
Results: 43 subjects with 87 bio-samples were identified, including 18 treatment-naïve subjects. Spearman's correlation at the enrolment visit was strong (rs = 0.78) with similar results seen in the treatment-naïve cohort (rs = 0.63). This relationship persisted over time, with linear mixed modelling of the treatment-naïve cohort showing beta-coefficient for the IRG-Score of 0.004 with p-value <0.001.
Conclusion: This study shows evidence of a significant correlation between IRG-score and disease activity, which is maintained over time. This highlights the potential for IRG-score to be an important biomarker in JDM.
期刊介绍：
The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
