IF 10.6 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Xiaoting Zhou, Jiaqi Liao, Zipeng Lei, Huiqin Yao, Le Zhao, Chun Yang, Yan Zu, Yuliang Zhao
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引用次数: 0

摘要

镍基纳米材料(NBNs)在各种应用领域的使用激增。然而,镍基纳米材料的广泛使用已导致人类接触镍基纳米材料的机会增加,从而引发了短期和长期的相关健康风险问题。此外,国家宽带网络在环境中的传播也引起了相当大的关注,成为研究和开发的一个重要焦点。本综述旨在深入评估目前对 NBN 毒性的认识、其毒理学效应的机制以及降低相关健康风险的策略。我们首先研究了 NBN 的物理化学特性,如粒度、成分和表面功能化,这些是决定其生物相互作用和毒性的关键因素。然后,通过对体外和体内研究的广泛分析,我们强调了接触 NBNs 的不良影响,包括活性氧(ROS)的产生、氧化应激、炎症、细胞毒性、遗传毒性和免疫毒性。为了应对与纳米宽带网络相关的潜在健康风险,我们提出了未来的风险预防策略,包括开发更安全的纳米材料设计、实施严格的监管准则以及推进新型毒性测试方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nickel-based nanomaterials: a comprehensive analysis of risk assessment, toxicity mechanisms, and future strategies for health risk prevention.

Nickel-based nanomaterials (NBNs) have seen a surge in usage across a variety of applications. However, the widespread use of NBNs has led to increased human exposure, raising questions about their associated health risks, both in the short and long term. Additionally, the spread of NBNs in the environment has attracted considerable attention, emerging as a vital focus for research and development. This review aims to provide an in-depth assessment of the current understanding of NBNs toxicity, the mechanisms underlying their toxicological effects, and the strategies for mitigating associated health risks. We begin by examining the physicochemical properties of NBNs, such as particle size, composition and surface functionalization, which are key determinants of their biological interactions and toxicity. Then, through an extensive analysis of in vitro and in vivo studies, we highlight the adverse effects of NBNs exposure, including the generation of reactive oxygen species (ROS), oxidative stress, inflammation, cytotoxicity, genotoxicity, and immunotoxicity. To address the potential health risks associated with NBNs, we propose future strategies for risk prevention, including the development of safer nanomaterial designs, implementation of stringent regulatory guidelines, and advancement of novel toxicity testing approaches.

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来源期刊
Journal of Nanobiotechnology
Journal of Nanobiotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
13.90
自引率
4.90%
发文量
493
审稿时长
16 weeks
期刊介绍: Journal of Nanobiotechnology is an open access peer-reviewed journal communicating scientific and technological advances in the fields of medicine and biology, with an emphasis in their interface with nanoscale sciences. The journal provides biomedical scientists and the international biotechnology business community with the latest developments in the growing field of Nanobiotechnology.
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