Shiran Sara Moore, Anie Lapointe, Emmanouil Rampakakis, Jessica Simoneau, Pierre Elias, Alishia Poccia, Asim Al Balushi, Adel Schwertani, Pia Wintermark, Gabriel Altit
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引用次数: 0
摘要
目的：探讨新生儿脑病（NE）新生儿心脏生物标志物与心室功能超声心动图参数的相关性。方法：前瞻性观察研究（2016-2021）对接受治疗性低温（TH）的新生儿进行研究。脑损伤新生儿在生命第2、3、4和10天重复超声心动图和生物标志物测量。使用Pearson相关和广义线性混合效应模型来解释重复测量。构建受试者工作特征曲线以评估敏感性/特异性。结果：56例新生儿有128项测量。肌酸激酶（CK）和心肌肌钙蛋白- i （CTn-I）与右心室（RV）功能相关。CK为1961 U/L， ctn - 1为91 ng/L，表明低三尖瓣环形平面收缩漂移(结论：CK和ctn - 1升高与右心室功能下降有关。趋势这些标记物可用于怀疑左室功能改变，并可能标记最佳时机的评价超声心动图在TH期间。
Cardiac biomarkers predict low right ventricle performance in neonatal encephalopathy.
Objective: Study the association between cardiac biomarkers and echocardiography parameters of ventricular performance in neonates with neonatal encephalopathy (NE).
Methods: Prospective observational study (2016-2021) of neonates undergoing therapeutic hypothermia (TH). Neonates with brain injury had repeated echocardiography and biomarkers measurements on day of life (DOL) 2, 3, 4, and 10. Pearson correlation and generalized linear mixed effect models were used to account for repeated measurements. Receiver operating characteristic curves were constructed to assess sensitivity/specificity.
Results: 56 neonates had 128 measurements. Creatine Kinase (CK) and cardiac troponin-I (CTn-I) were associated with right ventricular (RV) function. A CK of 1961 U/L and a CTn-I of 91 ng/L identified low Tricuspid Annular Plane Systolic Excursion (<7 mm) with sensitivities of 93% and 79%, and specificities of 55% and 74%, respectively.
Conclusions: Elevated CK and CTn-I were associated with decreased RV performance. Trending these markers can be used to suspect altered RV function and may flag optimal timing for evaluation(s) by echocardiography during TH.
期刊介绍：
The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development.
The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.
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