《文摘》：对于长期处于瓶颈期的物种来说，弱有害突变是否会加剧生殖和健康方面的挑战？

IF 3.1 2区环境科学与生态学 Q2 ECOLOGY

Evolution Pub Date : 2025-03-16 DOI:10.1093/evolut/qpaf046

Aryan Ghader

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引用次数: 0

摘要

弱有害突变是否会对瓶颈物种的生殖和健康造成挑战？Peers等人（2025）研究了长期低有效种群规模在猎豹（Acinonyx jubatus）中的作用及其对假基因积累的影响。他们确定了65个猎豹特有的过早终止密码子，其中4个（DEFB116、ARL13A、CFAP119和NT5DC4）与雄性生育能力和免疫缺陷有关。这些发现揭示了伪化如何导致生育挑战和生殖健康下降。

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Digest: Do weakly deleterious mutations exacerbate reproductive and health challenges in species with prolonged bottlenecks?

Do weakly deleterious mutations contribute to the reproductive and health challenges of bottlenecked species? Peers et al. (2025) investigated the role of prolonged low effective population size in cheetahs (Acinonyx jubatus) and its implications in the accumulation of pseudogenes. They identified 65 cheetah-specific premature termination codons, four of which (DEFB116, ARL13A, CFAP119, and NT5DC4) were linked to male fertility and immune deficiencies. These findings reveal how pseudogenization may contribute to fertility challenges and reproductive health decline.

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来源期刊

Evolution 环境科学-进化生物学

CiteScore

5.00

自引率

9.10%

发文量

审稿时长

3-6 weeks

期刊介绍： Evolution, published for the Society for the Study of Evolution, is the premier publication devoted to the study of organic evolution and the integration of the various fields of science concerned with evolution. The journal presents significant and original results that extend our understanding of evolutionary phenomena and processes.