中国人群中棕榈亮酸和神经酸己糖神经酰胺与2型糖尿病的关联：一项前瞻性巢式病例对照研究

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2025-03-15 DOI:10.1080/07435800.2025.2479256

Chuyi Ruan, Jun Sun, Xiaoqing Liang, Hong Huang, Mingzhi Zhang, Shaoyan Zhang

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引用次数: 0

摘要

目的：我们旨在评估己糖神经酰胺（HexCers）及其比例与2型糖尿病（T2DM）发病率的关系，并探讨其潜在机制。方法：采用巢式病例-对照研究，选取苏州慢性疾病队列，其中T2DM患者234例，对照组468例，年龄（±2岁）和性别1:2匹配。采用靶向UPLC-MS/MS法测定HexCer（d18:1/16:1）和HexCer（d18:1/24:1）。使用多变量条件逻辑回归来估计这些HexCer种类及其比例与T2DM风险的关系。结果：调整潜在混杂因素后，与最低四分位数相比，最高四分位数的HexCer（d18:1/24:1）与T2DM风险呈正相关(OR: 1.91；95%ci, 1.12, 3.26；结论：在中国社区人群中，HexCer（d18:1/24:1）及其与HexCer（d18:1/16:1）的比值与T2DM发病呈正相关。未来的研究将证实我们的发现。

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Associations of Palmito-leic Acid and Nervonic Acid Hexosylceramides with Type 2 Diabetes Mellitus in a Prospective Nested Case-control Study Among Chinese Population.

Objectives: We aimed to evaluate the associations of hexosylceramides (HexCers) and their ratio with incident type 2 diabetes mellitus (T2DM) and explore underlying mechanisms.

Methods: We conducted a nested case-control study using the Suzhou chronic disease cohort including 234 T2DM cases and 468 controls, 1:2 matched on age (±2 y) and sex. HexCer(d18:1/16:1) and HexCer(d18:1/24:1) were measured by targeted UPLC-MS/MS. Multivariable conditional logistic regression was used to estimate the associations of these HexCer species and their ratio with T2DM risk.

Results: After adjustment for potential confounders, compared with the lowest quartile, the highest quartile of HexCer(d18:1/24:1) was positively associated with T2DM risk (OR: 1.91; 95%CI, 1.12, 3.26; P-trend <0.05). The ratio of HexCer(d18:1/24:1) to HexCer(d18:1/16:1) showed a positive association with T2DM risk (OR: 1.89; 95%CI, 1.13, 3.18; P-trend <0.05). On the natural log scale, each SD increases in HexCer(d18:1/24:1) and its ratio to HexCer(d18:1/16:1) increased by 29% and 30%, respectively. No significant association for HexCer(d18:1/16:1) was found. Additive value of HexCer(d18:1/24:1) or HexCer(d18:1/24:1)/HexCer(d18:1/16:1) ratio for prediction of T2DM above traditional risk factors.

Conclusions: HexCer(d18:1/24:1) and its ratio to HexCer(d18:1/16:1) are positively associated with incident T2DM in a community-based Chinese population. Future studies are warranted to confirm our findings.

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.