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IF 2 3区医学 Q2 PEDIATRICS

BMC Pediatrics Pub Date : 2025-03-15 DOI:10.1186/s12887-025-05536-5

Fatemeh Pourjoula, Seyed Hossein Mirlohi, Niloufar Ghanbari

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引用次数: 0

摘要

背景：SARS-CoV-2的Omicron变异型与儿童独特的临床表现有关，包括类似于麦粒肿的症状，如犬吠样咳嗽、声音嘶哑和呼吸窘迫。本研究旨在比较在 Omicron 波期间 COVID-19 检测呈阳性或阴性的住院儿童哮喘患者的临床、实验室和治疗特征：该研究对 2022 年 1 月 21 日至 3 月 20 日期间在伊朗 Bahrami 儿童医院和儿童医疗中心住院的 111 名儿童哮喘患者进行了回顾性、描述性分析研究。患者被分为两组：PCR阳性组（奥米克隆组，n = 30）和PCR阴性组（非奥米克隆组，n = 81）。采用 SPSS 20 版提取并分析了人口统计学、临床严重程度、实验室指标、治疗和结果等方面的数据：欧米克隆组的平均年龄（16.93 ± 24.80 个月）明显小于非欧米克隆组（32.58 ± 37.26 个月；P = 0.049）。欧米克隆组的症状严重程度更高，73.4% 的患者出现中度至重度症状，而非欧米克隆组仅为 32.1%（p = 0.001）。奥米克隆组的住院时间更长（2.59 ± 3.93 对 2.11 ± 2.75 天；p = 0.016），需要更多的雾化肾上腺素（2.47 ± 1.27 对 1.77 ± 1.003 天；p = 0.003）和重复皮质类固醇剂量（83.3% 对 38.3%；p = 0.0001）。实验室检查结果显示，各组间无明显差异（所有组间差异均大于 0.05）：结论：与未患 COVID-19 的儿童相比，奥米克龙激增期间患儿的症状更严重，需要更多的强化治疗，住院时间更长。这些研究结果表明，在儿科人群中，需要提高临床意识，并针对与奥米克龙相关的气团病采取有针对性的管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comparative analysis of croup severity and treatment in pediatric patient: a study of COVID-19 positive vs. negative cases during peak Omicron.

Background: The Omicron variant of SARS-CoV-2 has been associated with unique clinical presentations in children, including croup-like symptoms such as barking cough, hoarseness, and respiratory distress. This study aimed to compare the clinical, laboratory, and treatment characteristics of hospitalized pediatric patients with croup who tested positive or negative for COVID-19 during the Omicron wave.

Methods: A retrospective, descriptive-analytical study was conducted on 111 pediatric patients hospitalized with croup at Bahrami Children's Hospital and the Children's Medical Center in Iran from January 21 to March 20, 2022. Patients were categorized into two groups: PCR-positive (Omicron group, n = 30) and PCR-negative (non-Omicron group, n = 81). Data on demographics, clinical severity, laboratory indices, treatments, and outcomes were extracted and analyzed using SPSS version 20.

Results: The mean age of the Omicron group was significantly younger (16.93 ± 24.80 months) compared to the non-Omicron group (32.58 ± 37.26 months; p = 0.049). Symptom severity was higher in the Omicron group, with moderate to severe symptoms observed in 73.4% of patients, compared to 32.1% in the non-Omicron group (p = 0.001). The Omicron group had longer hospital stays (2.59 ± 3.93 vs. 2.11 ± 2.75 days; p = 0.016) and required more nebulized epinephrine (2.47 ± 1.27 vs. 1.77 ± 1.003 days; p = 0.003) and repeat corticosteroid doses (83.3% vs. 38.3%; p = 0.0001). Laboratory findings showed no significant differences between the groups (all p > 0.05).

Conclusion: Children with croup during the Omicron surge exhibited increased symptom severity, required more intensive treatment, and experienced longer hospital stays compared to those without COVID-19. These findings emphasize the need for heightened clinical awareness and tailored management strategies for Omicron-related croup in pediatric populations.

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来源期刊

BMC Pediatrics PEDIATRICS-

CiteScore

3.70

自引率

4.20%

发文量

683

审稿时长

3-8 weeks

期刊介绍： BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.