安非他明的使用与青春期和青年期的心理健康问题：四项澳大利亚队列研究的综合数据分析。

IF 5.2 1区医学 Q1 PSYCHIATRY

Addiction Pub Date : 2025-03-15 DOI:10.1111/add.70033

Christopher J Greenwood, James Foulds, Rebecca McKetin, Stephanie R Aarsman, Delyse Hutchinson, Jessica Kerr, Jessica A Heerde, John W Toumbourou, Joseph M Boden, Tim Slade, Yvonne Bonomo, Primrose Letcher, Craig A Olsson

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引用次数: 0

摘要

背景和目的：使用安非他明（包括安非他明和甲基苯丙胺）一直与精神健康问题有关；然而，潜在因果关系的方向尚未确定。本研究旨在评估青春期和青年期非法使用安非他明与心理健康问题之间的方向关系。设计：对参与监测非法物质使用（滥用）联盟的四个人群水平队列进行观察性研究。地理位置：澳大利亚和新西兰。参与者：共7527名参与者（51%为女性）：克赖斯特彻奇健康与发展研究（n = 1056）、澳大利亚气质项目（n = 1644）、维多利亚青少年健康队列研究（n = 1943）和国际青年发展研究（n = 2884）。测量方法：通过评估得出青春期（10-17岁）和青年期（18-30岁）苯丙胺使用（≥每月）和心理健康问题的二元指标。研究结果：使用g计算程序估计相关性为95%置信内值（ci）的风险比（rr），同时考虑15个潜在的混杂因素以及暴露与研究队列和参与者性别之间的相互作用。那些在青春期每月或更频繁使用安非他明的人，在青年期出现精神健康问题的风险高出21% （RR = 1.21, 95% CI = 1.04, 1.41）。在青少年时期报告有心理健康问题的人群中，青年期每月或更高剂量使用安非他明的风险高出19% （RR = 1.19, 95% CI = 0.99, 1.45）。也有一些证据表明，在男性中，使用安非他命与心理健康问题的相关性最强（RR = 1.24, 95% CI = 0.95, 1.60），而在女性中，使用安非他命与心理健康问题的相关性最强（RR = 1.33, 95% CI = 0.99, 1.78）。结论：从青春期到青年期，每月或更频繁地使用安非他命与心理健康问题之间似乎存在双向关联。

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Amphetamine use and mental health difficulties across adolescence and young adulthood: An integrative data analysis of four Australasian cohort studies.

Background and aims: The use of amphetamines (including amphetamine and methamphetamine) has been consistently associated with mental health difficulties; however, the direction of potential causal relationships has not yet been established. This study aimed to assess the direction relationships between illicit amphetamine use and mental health difficulties across adolescence and young adulthood.

Design: Observational study of four population-level cohorts participating in the Monitoring Illicit Substance Use (MISUse) Consortium.

Setting: Australia and New Zealand.

Participants: A total of 7527 participants (51% female) were used: Christchurch Health and Development Study (n = 1056), Australian Temperament Project (n = 1644), Victorian Adolescent Health Cohort Study (n = 1943) and International Youth Development Study (n = 2884).

Measurements: Assessments were used to derive binary indicators of amphetamine use (≥monthly) and mental health difficulties during both adolescence (age 10-17 years) and young adulthood (age 18-30 years).

Findings: Associations were estimated as Risk Ratios (RRs) with 95% confidence internals (CIs) using G-computation procedures, while accounting for 15 potential confounding factors and interactions between exposure and both study cohort and participant sex. The risk of mental health difficulties in young adulthood was 21% greater (RR = 1.21, 95% CI = 1.04, 1.41) for those who reported monthly or more frequent amphetamine use in adolescence. The risk of monthly or higher amphetamine use in young adulthood was 19% greater (RR = 1.19, 95% CI = 0.99, 1.45) in those who reported mental health difficulties in adolescence. There was also some evidence to suggest that in males the strongest association was from amphetamine use to mental health difficulties (RR = 1.24, 95% CI = 0.95, 1.60), while in females the strongest association was from mental health difficulties to amphetamine use (RR = 1.33, 95% CI = 0.99, 1.78).

Conclusions: There appears to be a bidirectional association between monthly or more frequent amphetamine use and mental health difficulties from adolescence to young adulthood.

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来源期刊

Addiction 医学-精神病学

CiteScore

10.80

自引率

6.70%

发文量

319

审稿时长

3 months

期刊介绍： Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines. Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries. Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.