Yuansheng Wu, Yingjie Zhu, Jie Chen, Lili Song, Chunping Wang, Yanglin Wu, Yanyang Chen, Jiancheng Zheng, Yuankun Zhai, Xiang Zhou, Youwen Liu, Yawei Du, Wenguo Cui
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Boosting mRNA-Engineered Monocytes via Prodrug-Like Microspheres for Bone Microenvironment Multi-Phase Remodeling (Adv. Healthcare Mater. 7/2025)
Injectable mRNA Microplexes
In article 2403212, Youwen Liu, Yawei Du, Wenguo Cui, and co-workers introduce an injectable microplex system that combines IL-4 mRNA lipid nanoparticles (LNPs) with icariin prodrug-like microspheres to achieve in-situ regulation of monocytes for tissue regeneration. The prodruglike microspheres enable the sustained release of both icariin and LNPs, facilitating multi-phase remodeling of the osteoclastic microenvironment and effective monocyte engineering. This innovative injectable mRNA microplex system successfully addresses the challenges of bone defect repair caused by inflammation and excessive osteoclast activity.
期刊介绍：
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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