脂质纳米粒子介导的 CRISPR-Cas13a 释放技术用于控制细菌感染（Adv.）

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-03-17 DOI:10.1002/adhm.202570040

Bookun Kim, Hwi Won Seo, Kyuri Lee, Dongeun Yong, Yoon Kyung Park, Yujin Lee, Solip Lee, Do-Wan Kim, Dajeong Kim, Choong-Min Ryu

{"title":"脂质纳米粒子介导的 CRISPR-Cas13a 释放技术用于控制细菌感染（Adv.）","authors":"Bookun Kim, Hwi Won Seo, Kyuri Lee, Dongeun Yong, Yoon Kyung Park, Yujin Lee, Solip Lee, Do-Wan Kim, Dajeong Kim, Choong-Min Ryu","doi":"10.1002/adhm.202570040","DOIUrl":null,"url":null,"abstract":"<p><b>Bacteria-Targeting Lipid Nanoparticle</b></p><p>In article 2403281, Dajeong Kim, Choong-Min Ryu, and co-workers develop a lipid nanoparticle (LNP) that can penetrate bacteria and deliver nucleic acids for the control of bacterial infection. Delivery of LNPs is achieved with the aid of “LNP-helpers”, yellow granules treated on the bacterial surface. The LNP is a novel antimicrobial platform that controls bacteria by delivering the CRISPR-Cas system as a weapon.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"14 7","pages":""},"PeriodicalIF":10.0000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202570040","citationCount":"0","resultStr":"{\"title\":\"Lipid Nanoparticle-Mediated CRISPR-Cas13a Delivery for the Control of Bacterial Infection (Adv. Healthcare Mater. 7/2025)\",\"authors\":\"Bookun Kim, Hwi Won Seo, Kyuri Lee, Dongeun Yong, Yoon Kyung Park, Yujin Lee, Solip Lee, Do-Wan Kim, Dajeong Kim, Choong-Min Ryu\",\"doi\":\"10.1002/adhm.202570040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Bacteria-Targeting Lipid Nanoparticle</b></p><p>In article 2403281, Dajeong Kim, Choong-Min Ryu, and co-workers develop a lipid nanoparticle (LNP) that can penetrate bacteria and deliver nucleic acids for the control of bacterial infection. Delivery of LNPs is achieved with the aid of “LNP-helpers”, yellow granules treated on the bacterial surface. The LNP is a novel antimicrobial platform that controls bacteria by delivering the CRISPR-Cas system as a weapon.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":113,\"journal\":{\"name\":\"Advanced Healthcare Materials\",\"volume\":\"14 7\",\"pages\":\"\"},\"PeriodicalIF\":10.0000,\"publicationDate\":\"2025-03-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202570040\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Healthcare Materials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202570040\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Healthcare Materials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202570040","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 0

摘要

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lipid Nanoparticle-Mediated CRISPR-Cas13a Delivery for the Control of Bacterial Infection (Adv. Healthcare Mater. 7/2025)

查看原文本刊更多论文

Lipid Nanoparticle-Mediated CRISPR-Cas13a Delivery for the Control of Bacterial Infection (Adv. Healthcare Mater. 7/2025)

Bacteria-Targeting Lipid Nanoparticle

In article 2403281, Dajeong Kim, Choong-Min Ryu, and co-workers develop a lipid nanoparticle (LNP) that can penetrate bacteria and deliver nucleic acids for the control of bacterial infection. Delivery of LNPs is achieved with the aid of “LNP-helpers”, yellow granules treated on the bacterial surface. The LNP is a novel antimicrobial platform that controls bacteria by delivering the CRISPR-Cas system as a weapon.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.