{"title":"SS-20四肽对线粒体和细胞的抗氧化作用研究","authors":"T. N. Goleva, V. O. Khvastunov, A. G. Rogov","doi":"10.1134/S2635167624602419","DOIUrl":null,"url":null,"abstract":"<p>A promising strategy for combating pathologies associated with oxidative stress is the use of mitochondria-targeted drugs. One of them is the positively charged tetrapeptide SS-20, which is able to penetrate into mitochondria. The effect of SS-20 on isolated supercoupled rat-liver mitochondria is studied. It is shown that SS-20 decreases hydrogen peroxide production, inhibits the opening of the nonspecific Ca<sup>2+</sup>/Pi-dependent mitochondrial pore, does not exhibit uncoupling activity, does not inhibit mitochondrial respiration, and does not reduce their membrane potential. In the aerobic yeast <i>Dipodascus magnusii</i>, SS-20 reduced the level of oxidative stress in yeast and prevented prooxidant-induced mitochondrial fragmentation.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":"19 6","pages":"1030 - 1037"},"PeriodicalIF":0.8000,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"On the Antioxidant Effect of SS-20 Tetrapeptide on Mitochondria and Cells\",\"authors\":\"T. N. Goleva, V. O. Khvastunov, A. G. Rogov\",\"doi\":\"10.1134/S2635167624602419\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A promising strategy for combating pathologies associated with oxidative stress is the use of mitochondria-targeted drugs. One of them is the positively charged tetrapeptide SS-20, which is able to penetrate into mitochondria. The effect of SS-20 on isolated supercoupled rat-liver mitochondria is studied. It is shown that SS-20 decreases hydrogen peroxide production, inhibits the opening of the nonspecific Ca<sup>2+</sup>/Pi-dependent mitochondrial pore, does not exhibit uncoupling activity, does not inhibit mitochondrial respiration, and does not reduce their membrane potential. In the aerobic yeast <i>Dipodascus magnusii</i>, SS-20 reduced the level of oxidative stress in yeast and prevented prooxidant-induced mitochondrial fragmentation.</p>\",\"PeriodicalId\":716,\"journal\":{\"name\":\"Nanotechnologies in Russia\",\"volume\":\"19 6\",\"pages\":\"1030 - 1037\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-03-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nanotechnologies in Russia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S2635167624602419\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanotechnologies in Russia","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1134/S2635167624602419","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Engineering","Score":null,"Total":0}
On the Antioxidant Effect of SS-20 Tetrapeptide on Mitochondria and Cells
A promising strategy for combating pathologies associated with oxidative stress is the use of mitochondria-targeted drugs. One of them is the positively charged tetrapeptide SS-20, which is able to penetrate into mitochondria. The effect of SS-20 on isolated supercoupled rat-liver mitochondria is studied. It is shown that SS-20 decreases hydrogen peroxide production, inhibits the opening of the nonspecific Ca2+/Pi-dependent mitochondrial pore, does not exhibit uncoupling activity, does not inhibit mitochondrial respiration, and does not reduce their membrane potential. In the aerobic yeast Dipodascus magnusii, SS-20 reduced the level of oxidative stress in yeast and prevented prooxidant-induced mitochondrial fragmentation.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
