T. V. Rakitina, V. I. Timofeev, A. S. Ivanovsky, A. V. Kalach, T. N. Gaeva, R. G. Vasilov
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Predicting the Immunogenic Potential of Herpes Virus Type 2 Glycoprotein B Antigenic Domains
Based on a combination of modeling and structural analysis methods with immunoinformatic algorithms for digital prediction, structural elements, i.e., subdomains, also called antigenic domains, enriched in B- and T-cell antigenic determinants (epitopes), of the surface ectodomain of glycoprotein B (EctoGB) of human herpes simplex virus type 2 are found and their immunogenicity, allergenicity, and toxicity are predicted. It is established that the proximal β-ribbon domain of EctoGB (subP) adjacent to the viral envelope has the maximum immunogenic potential, which corresponds to the results of an experimental analysis carried out on the EctoGB model of human herpes virus type 5. Further studies of subP will contribute to the development of a new antiherpetic vaccine, and the proposed methodology can be used to search for antigenic domains of viruses of various families.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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