电化学辅助弗里德兰德反应：一种高效、可持续的喹啉合成方法

IF 9.3 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Green Chemistry Pub Date : 2025-02-26 DOI:10.1039/d5gc00330j

Hamid Salehzadeh , Zahra Rostami Bigdeli , Kevin Lam

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引用次数: 0

摘要

Friedländer反应是一种公认的合成喹啉的方法。然而，它有很大的局限性，包括反应时间长，使用对环境有害的溶剂和试剂，以及产生大量废物。在这项研究中，我们提出了一种简单、可持续、高效的一步电合成策略，利用电流从现成的硝基化合物合成喹啉。这种无试剂的方法在温和的条件下使用恒流电解装置，并以优异的原子经济性实现高转化率。成功地合成了各种取代喹啉，收率很高。此外，通过循环伏安法和控制电位电解法研究了喹啉生成的反应机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Electrochemically assisted Friedlander reaction: a highly efficient and sustainable method for quinoline synthesis†

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Electrochemically assisted Friedlander reaction: a highly efficient and sustainable method for quinoline synthesis†

The Friedländer reaction is a well-established method for quinoline synthesis. However, it has significant limitations, including long reaction times, the use of environmentally harmful solvents and reagents, and significant waste generation. In this study, we present a simple, sustainable, efficient and one-step electrosynthetic strategy for the synthesis of quinolines from readily available nitro compounds using electric current. This reagent-free method operates under mild conditions with a constant-current electrolysis setup and achieves high conversion rates with excellent atom economy. Various substituted quinolines were successfully synthesised in good to excellent yields. In addition, cyclic voltammetry and controlled potential electrolysis studies were carried out to investigate the reaction mechanism of quinoline formation.

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来源期刊

Green Chemistry 化学-化学综合

CiteScore

16.10

自引率

7.10%

发文量

677

审稿时长

1.4 months

期刊介绍： Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.