Omicron轻度急性SARS-CoV-2感染的持续时间取决于先前的疫苗接种和感染-使用德国DigiHero队列研究的数据，该研究来自2022/2023和2023/2024大流行后冬季

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-03-12 DOI:10.1016/j.jiph.2025.102746

Nadine Glaser , Sophie Diexer , Bianca Klee , Janka Massag , Laura R. Pfrommer , Oliver Purschke , Mascha Binder , Thomas Frese , Matthias Girndt , Jessica I. Hoell , Irene Moor , Jonas Rosendahl , Michael Gekle , Daniel Sedding , Cornelia Gottschick , Rafael Mikolajczyk

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引用次数: 0

摘要

目的广泛研究COVID-19疫苗接种或感染后对SARS-CoV-2严重病程的保护作用。目前尚不清楚这种影响是否也会缩短轻度感染的持续时间。我们根据轻度感染个体的疫苗接种状况和既往SARS-CoV-2感染情况评估症状持续时间。方法在大流行后的两个冬季（2022/2023和2023/2024），德国DigiHero研究的13,615名参与者报告了9月至3月的SARS-CoV-2感染情况。通过调整社会人口因素的负二项回归，我们研究了感染持续时间（出现症状和卧床的天数）与疫苗接种次数、既往SARS-CoV-2感染以及距离上次疫苗接种/感染的时间之间的关系。结果短期轻度感染（有症状≤21天）的感染持续时间与疫苗接种次数和上次感染时间没有明显差异。自上次接种疫苗以来每6个月，症状持续时间和卧床天数分别增加了2% %和4% %。先前没有SARS-CoV-2感染的个体发生长期轻度SARS-CoV-2感染（有症状21天）的风险更高(优势比：1.98；95 %置信区间[1.43；2.76])，但接种疫苗不适用(OR: 0.98；95 % ci [0.74；1.33])。结论没有迹象表明短期轻度感染期间症状持续时间的缩短取决于疫苗接种次数和上次SARS-CoV-2疫苗接种或感染的时间。先前的SARS-CoV-2感染对轻度SARS-CoV-2感染的长期疾病具有保护作用。

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Duration of mild acute SARS-CoV-2 infections with Omicron depending on previous vaccinations and infections – Using data of the German DigiHero cohort study from post-pandemic winters 2022/2023 and 2023/2024

Objectives

Protection against severe course of SARS-CoV-2 infection after COVID-19 vaccination or infection was extensively studied. It is unknown whether this effect also translates into shortened duration of mild infections. We assessed the duration of symptoms depending on vaccination status and previous SARS-CoV-2 infections among individuals with a mild course of infection.

Methods

For two post-pandemic winters (2022/2023 and 2023/2024), in total 13,615 participants of the German DigiHero study reported their SARS-CoV-2 infections from September to March. Via negative binomial regression adjusting for sociodemographic factors, we studied the association of infection duration (days with symptoms and in bed) with number of vaccinations, prior SARS-CoV-2 infections, and time since last vaccination/and infection.

Results

We noted no major differences in infection duration depending on the number of vaccinations and time since last infection for short mild infections (≤21 days with symptoms). Per 6 months since the last vaccination, symptom duration and days spent in bed increased by 2 % and 4 %. The risk of long mild SARS-CoV-2 infections (>21 days with symptoms) was higher for individuals with no prior SARS-CoV-2 infection (Odds Ratio: 1.98; 95 % confidence interval [1.43; 2.76]), but not for vaccinations (OR: 0.98; 95 % CI [0.74; 1.33]).

Conclusions

There was no indication of reduced duration of symptoms during short mild infections depending on the number of vaccinations and time since the last SARS-CoV-2 vaccination or infection. A prior SARS-CoV-2 infection was protective against prolonged disease in mild SARS-CoV-2 infections.

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.