[低血容量性和出血性休克]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2025-03-01 Epub Date: 2025-03-14 DOI:10.1055/a-2295-1929
Stephan Braune, Martin Rieck, Angela Ginski
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引用次数: 0

摘要

低血容量性和失血性休克是危及生命的疾病,如果不及时治疗,会迅速导致多器官衰竭和死亡。这些情况是由大量血管内液体或血液流失引起的,造成严重的器官灌注不足。潜在的病理生理包括复杂的血液动力学、炎症和凝血障碍,这些障碍可能发展为不可逆的器官功能障碍。快速诊断,早期出血控制,有针对性的血流动力学和止血治疗是改善患者预后的关键。诊断是基于临床症状、实验室参数和成像或内窥镜评估。主要的治疗方法侧重于解决潜在的原因,同时实施液体复苏和血管加压剂支持。在失血性休克中,凝血管理是至关重要的。基本治疗原则包括维持正常体温、pH值高于7.2和正常钙血症。如果无禁忌症,应应用容许性低血压来限制持续出血。建议早期目标定向给药氨甲环酸和纤维蛋白原以稳定凝血。对于经历严重失血性休克的患者,必须优化输血策略。血红蛋白目标通常推荐为7-9g/dL,在需要大量输血的情况下,红细胞、血浆和血小板的比例应为4:4:1。此外,接受有效抗凝治疗的患者需要特定的逆转药物来恢复止血。总之,低血容量和失血性休克的成功治疗取决于早期识别、快速出血控制和个体化目标导向复苏和止血策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Hypovolaemic and haemorrhagic shock].

Hypovolemic and hemorrhagic shock are life-threatening conditions that, if untreated, rapidly lead to multi-organ failure and death. These conditions result from significant intravascular fluid or blood loss, causing critical organ hypoperfusion. The underlying pathophysiology involves complex hemodynamic, inflammatory, and coagulation disturbances that may progress to irreversible organ dysfunction. Rapid diagnosis, early hemorrhage control, and targeted hemodynamic and hemostatic therapy are crucial to improve patient outcomes. Diagnosis is based on clinical symptoms, laboratory parameters, and imaging or endoscopic assessments. The primary therapeutic approach focuses on addressing the underlying cause while implementing fluid resuscitation and vasopressor support. In hemorrhagic shock, coagulation management is of paramount importance. Essential treatment principles include maintaining normothermia, a pH above 7.2, and normocalcemia. If no contraindications exist, permissive hypotension should be applied to limit ongoing bleeding. Early goal directed administration of tranexamic acid and fibrinogen is recommended to stabilize coagulation. For patients experiencing severe hemorrhagic shock, transfusion strategies must be optimized. A hemoglobin target of 7-9g/dL is generally recommended, and in cases requiring massive transfusion, a ratio of red blood cells, plasma, and pooled platelets of 4:4:1 should be used. Additionally, patients receiving effective anticoagulation require specific reversal agents to restore hemostasis. In summary, the successful management of hypovolemic and hemorrhagic shock depends on early recognition, rapid hemorrhage control, and individualized goal directed resuscitation and hemostatic strategies.

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