甲胎蛋白（AFP）在妊娠36周时减少，注定要分娩小于胎龄的婴儿。

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-03-10 DOI:10.1016/j.ejogrb.2025.03.027

Joshua Masci , Manju Kandel , Susan P. Walker , Ping Cannon , Tuong-Vi Nguyen , Georgia P. Wong , Teresa M. MacDonald , Natalie J. Hannan , Tu’uhevaha J. Kaitu’u-Lino , Lucy A. Bartho

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引用次数: 0

摘要

甲胎蛋白（AFP）是一种常用于筛查妊娠非整倍体的蛋白质。这项研究测量了妊娠 36 周时，在确诊子痫前期或分娩小于胎龄儿（SGA）之前，母体血浆中循环甲胎蛋白的含量；

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Alpha-fetoprotein (AFP) is reduced at 36 weeks’ gestation in pregnancies destined to deliver small for gestational age infants

Alpha-fetoprotein (AFP) is a protein commonly used to screen for aneuploidy in pregnancy. This study measured circulating AFP in maternal plasma at 36 weeks’ gestation preceding diagnosis of term preeclampsia or delivery of a small for gestational age infant (SGA; <10 % birthweight centile) in a case-cohort design (122 SGA; 23 preeclampsia; 182 controls). AFP was significantly reduced in SGA < 5th birthweight centile (n = 51; P = 0.002) but not changed preceding preeclampsia diagnosis. This suggests that AFP is reduced near term preceding SGA diagnosis and may have potential as a biomarker if combined with other candidate molecules.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.