宫颈癌患者不同体重等级与生存结局的关系

IF 2.4 3区医学 Q3 ONCOLOGY

Cancer Epidemiology Pub Date : 2025-03-15 DOI:10.1016/j.canep.2025.102801

Szu-Ying Tsai , Ming-Chieh Tsai , Min-Shu Hsu , Li-Wei Tsai , Heng-Cheng Hsu , Jing-Rong Jhuang , Chun-Ju Chiang , Wen-Chung Lee , Kuo-Liong Chien , Hsin-Yin Hsu , Tzu-Lin Yeh

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引用次数: 0

摘要

背景宫颈癌患者不同体重等级与死亡风险之间的关系尚不明确。因此，我们进行了这项研究，以评估不同体重类别与宫颈癌患者生存结果之间的关系。方法采用回顾性队列研究，纳入台湾省癌症登记数据库中的6908例宫颈癌患者。采用COX回归模型评估不同体重类别与三年总生存率和癌症特异性生存率的时间到事件结局之间的关系。结果中位随访时间为4.64 ± 2.55年。我们的研究显示，体重不足组的总体死亡风险显著高于正常体重组[风险比(HR) = 1.65,95 %可信区间(CI) = 1.37,1.99]。与对照组相比，超重患者总体死亡风险显著降低（HR = 0.81, 95 % CI = 0.71, 0.93），而肥胖组总体死亡风险显著降低（HR = 0.92, 95 % CI = 0.75, 1.13）。结论在控制混杂因素后，体重过轻的宫颈癌患者总体死亡风险高于体重正常的宫颈癌患者。我们的研究表明，与体重正常的宫颈癌患者相比，体重不足的宫颈癌患者总体死亡风险更高。此外，超重患者总体死亡风险明显较低。需要制定更多的战略，特别是在公共卫生领域，解决妇女体重等级和癌症死亡率问题。

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The association of different body weight classes and survival outcomes in patients with cervical cancer

Background

The relationship between different weight class and mortality risk remained uncertain in cervical cancer patients. Thus, we conducted the study to assess the association between different body weight classes and survival outcomes in patients with cervical cancer.

Methods

This was a retrospective cohort study including 6908 cervical cancer patients from the Taiwan Cancer Registry database. A COX regression model was used to evaluate the relationship between different weight classes and time-to-event outcomes of overall survival and cancer-specific survival at three years.

Results

The median follow-up time was 4.64 ± 2.55 years. Our study revealed that the underweight group had a significantly higher risk of overall death [hazard ratio (HR) = 1.65, 95 % confidence interval (CI) = 1.37, 1.99] than the normal-weight group. Overweight patients had a significantly lower risk of overall death (HR = 0.81, 95 % CI = 0.71, 0.93), whereas the obesity group had an insignificant lower risk of overall death (HR = 0.92, 95 % CI = 0.75, 1.13) compared with the reference group.

Conclusion

After controlling for confounding factors, underweight patients with cervical cancer had a higher risk of overall death than normal-weight patients with cervical cancer. Our study indicates that underweight cervical cancer patients had a higher risk of overall death compared with normal-weight cervical cancer patients. Furthermore, the overweight patients had a significantly lower risk of overall death. More strategies are needed to be addressed especially in public health field regarding women’s weight class and cancer mortality issues.

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来源期刊

Cancer Epidemiology 医学-肿瘤学

CiteScore

4.50

自引率

3.80%

发文量

200

审稿时长

39 days

期刊介绍： Cancer Epidemiology is dedicated to increasing understanding about cancer causes, prevention and control. The scope of the journal embraces all aspects of cancer epidemiology including: • Descriptive epidemiology • Studies of risk factors for disease initiation, development and prognosis • Screening and early detection • Prevention and control • Methodological issues The journal publishes original research articles (full length and short reports), systematic reviews and meta-analyses, editorials, commentaries and letters to the editor commenting on previously published research.