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IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Pub Date : 2025-02-18 DOI:10.1016/j.nut.2025.112718

Shinichiro Kodama M.D. , Nafuko Konishi M.D., Ph.D. , Yuriko Hirai B.A. , Akinori Fujisawa M.D. , Mitsuko Nakata Ph.D. , Satoshi Teramukai Ph.D. , Masanori Fukushima M.D., Ph.D.

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引用次数: 0

摘要

背景据报道，感染 COVID-19 和接种疫苗后都会出现长时间的症状，有些病例会导致肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）。在我院就诊的 80 名疫苗接种后综合征患者中，有 28 人符合 ME/CFS 的诊断标准。我们对这28名患者进行了一项回顾性研究。方法我们测量了2022年8月至2024年2月期间接种COVID-19疫苗后出现ME/CFS的28名患者的血清25-羟维生素D水平。维生素 D 替代疗法包括饮食咨询、阳光照射建议和口服维生素 D 补充剂。我们评估了血液中维生素 D 水平的变化和症状的改善情况。结果在初诊时，28 名确诊为 ME/CFS 的患者中有 27 人的血清 25- 羟维生素 D 水平不足或缺乏（16 ± 4 ng/mL，平均值 ± SD）。在接受维生素 D 替代治疗后，我们观察到血液中维生素 D 水平的增加（28 ± 5 ng/mL）与 ME/CFS 诊断症状的减少（从 10.3 ± 2.1 降至 3.3 ± 2.0）有关。值得注意的是，28 名患者中有 23 人（82%）在接受治疗后不再符合 ME/CFS 诊断标准。结论对于接种COVID-19疫苗后出现维生素D水平不足或缺乏的ME/CFS患者，在医生指导下进行适当的维生素D补充治疗可缓解症状。我们正准备进行一项随机对照试验，以评估维生素D替代疗法对感染或接种COVID-19疫苗后出现维生素D缺乏症的ME/CFS患者的疗效。

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Efficacy of vitamin D replacement therapy on 28 cases of myalgic encephalomyelitis/chronic fatigue syndrome after COVID-19 vaccination

Background

Prolonged symptoms have been reported following both COVID-19 infection and vaccination, with some cases leading to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Of 80 patients presenting to our hospital with postvaccination syndrome, 28 met the diagnostic criteria for ME/CFS. We conducted a retrospective study on these 28 patients.

Methods

We measured serum 25-hydroxyvitamin D levels in 28 patients who developed ME/CFS after COVID-19 vaccination between August 2022 and February 2024. Vitamin D replacement therapy included dietary counseling, sun exposure recommendations, and oral vitamin D supplementation. We evaluated changes in blood vitamin D levels and symptom improvement.

Results

At initial visit, 27 of 28 patients diagnosed with ME/CFS had insufficient or deficient serum 25-hydroxyvitamin D levels (16 ± 4 ng/mL, mean ± SD). Following vitamin D replacement therapy, we observed an increase in blood vitamin D levels (28 ± 5 ng/mL) associated with a decrease in ME/CFS diagnostic symptoms (from 10.3 ± 2.1 to 3.3 ± 2.0). Notably, 23 of 28 patients (82%) no longer met ME/CFS diagnostic criteria after the therapy. Among the symptoms, sleep problems showed the most improvement (71%), followed by autonomic symptoms (68%).

Conclusions

For patients developing ME/CFS after COVID-19 vaccination with insufficient or deficient vitamin D levels, appropriate vitamin D replacement therapy under medical guidance may lead to symptomatic relief. We are preparing a randomized controlled trial to evaluate the efficacy of vitamin D replacement therapy in individuals with ME/CFS who have developed vitamin D deficiency following COVID-19 infection or vaccination.

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.