用于无标记DNA检测的无结介质调制双栅GaNFET生物传感器的设计与分析

Md. Zahid Hasan , Rezaur Raihan , Nur Kutubul Alam , Md. Rejvi Kaysir , Md. Shaharuf Islam , M. A. Parvez Mahmud
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引用次数: 0

摘要

DNA杂交的研究跨越了各个科学领域,提供了从基因组学到诊断学和药理学的见解。传统的方法包括标记DNA,但创新的FET器件使用无标记技术。与传统方法相比,纳米级生物传感器具有更高的速度、灵敏度、成本效益和通用性。克服短通道效应(SCE)等挑战对于合成符合这些标准的生物传感器至关重要。以前的研究主要集中在无结双栅晶体管上,以减轻SCE和GaN作为高速,低功耗应用的通道材料。然而,由于介电常数和界面电荷效应的冲突,处理带负电荷的生物分子(如DNA)面临挑战。为了解决这些挑战,提出的纳米级生物传感器采用无结介质调制双栅GaN场效应晶体管(JL-DM-DG GaNFET)。该器件以氮化镓作为通道材料,有效地协同了相互冲突的介电常数和电荷效应。仿真结果表明,n型JL-DM-DG GaNFET对带负电荷的DNA具有显著的敏感性,阈值电压(>;k = 1至k = 15时为539 mV),而p型(k = 1至k = 4时为-101 mV, k = 4至k = 15时为74.59 mV)。具体来说,对于电荷密度,n型器件显示出更高的灵敏度(1.05 vs. 0.509),对于p型和介电常数k = 16 (n型灵敏度0.8 vs. p型灵敏度0.4)。此外,该器件显示出低亚阈值斜率(~ 60 mV/衰减)和更高的离子/ off比,表明更快的开关和更低的功耗。综上所述,所提出的n型JL-DM-DG GaNFET在高效可靠的DNA检测方面具有相当大的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Design and analysis of junctionless dielectric modulated double-gate GaNFET biosensor for label-free DNA detection

Design and analysis of junctionless dielectric modulated double-gate GaNFET biosensor for label-free DNA detection
The investigation of DNA hybridization spans various scientific domains, offering insights from genomics to diagnostics and pharmacology. Traditional methods involve labeling DNA, but innovative FET devices use label-free techniques. Nanoscale biosensors provide superior speed, sensitivity, cost-effectiveness, and versatility compared to conventional methods. Overcoming challenges like the Short Channel Effect (SCE) is crucial for synthesizing biosensors meeting these criteria. Previous research focused on junctionless double-gate transistors for mitigating SCE and GaN as channel materials for high-speed, low-power applications. However, dealing with negatively charged biomolecules like DNA poses challenges due to conflicting dielectric constant and interface charge effects. To address these challenges, the proposed nanoscale biosensor employs a junctionless dielectric modulated double-gate GaN field-effect transistor (JL-DM-DG GaNFET). This device effectively synergizes conflicting dielectric constant and charge effects, with GaN as the channel material. Simulation results show the n-type JL-DM-DG GaNFET exhibits significant sensitivity to negatively charged DNA, with a greater change in threshold voltage (> 539 mV for k = 1 to k = 15) compared to the p-type (-101 mV for k = 1 to k = 4, and 74.59 mV for k = 4 to k = 15). Specifically, for charge density the n-type device displays a higher sensitivity 1.05 vs. 0.509 for the p-type and for dielectric constant k = 16 (sensitivity 0.8 for n-type vs. 0.4 for p-type). Additionally, the device shows low subthreshold slope (∼ 60 mV/decay) and higher Ion/Ioff ratio, suggesting faster switching and lower power consumption. In summary, the proposed n-type JL-DM-DG GaNFET holds considerable potential for efficient and reliable DNA detection.
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