MXenes在联合治疗中的应用:化学光热,化学动力,光热/光动力治疗癌症和抗菌应用

IF 6.2 3区 材料科学 Q2 CHEMISTRY, PHYSICAL
Masoomeh Amoozadeh , Atefeh Zarepour , Arezoo Khosravi , Siavash Iravani , Ali Zarrabi
{"title":"MXenes在联合治疗中的应用:化学光热,化学动力,光热/光动力治疗癌症和抗菌应用","authors":"Masoomeh Amoozadeh ,&nbsp;Atefeh Zarepour ,&nbsp;Arezoo Khosravi ,&nbsp;Siavash Iravani ,&nbsp;Ali Zarrabi","doi":"10.1016/j.flatc.2025.100849","DOIUrl":null,"url":null,"abstract":"<div><div>Two-dimensional MXenes and their derivatives have attracted significant attention in recent years for their potential applications in combination therapies, specifically in chemo-photothermal, chemodynamic, and photothermal/photodynamic treatments. MXenes offer distinct advantages in combination therapies due to their exceptional electrical conductivity, hydrophilicity, large surface area, tunable surface chemistry, and ability to enhance drug delivery and therapeutic efficacy through multifunctional applications. By incorporating MXenes into combination therapies, researchers have demonstrated enhanced therapeutic efficacy through synergistic mechanisms that improve drug delivery, increase localized heating, and amplify the generation of reactive oxygen species, thereby effectively targeting and eliminating cancer cells or contaminations. However, stability in biological environments remains a primary concern, as degradation can compromise their therapeutic effectiveness and safety. Ensuring biocompatibility is crucial, since the introduction of MXenes and their composites may trigger immune responses or cytotoxicity. Moreover, optimizing the synthesis of high-quality MXenes with uniform properties remains a logistical challenge, affecting reproducibility and scalability for clinical applications. By consolidating existing knowledge and identifying future directions, this review aims to advance MXene-based combination chemo-photothermal, chemodynamic, and photothermal/photodynamic therapies for cancer treatment and antibacterial applications, ultimately paving the way for innovative strategies in biomedicine and personalized medicine.</div></div>","PeriodicalId":316,"journal":{"name":"FlatChem","volume":"51 ","pages":"Article 100849"},"PeriodicalIF":6.2000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"MXenes in combination therapy: Chemo-photothermal, chemodynamic, and photothermal/photodynamic therapies for cancer treatment and antibacterial applications\",\"authors\":\"Masoomeh Amoozadeh ,&nbsp;Atefeh Zarepour ,&nbsp;Arezoo Khosravi ,&nbsp;Siavash Iravani ,&nbsp;Ali Zarrabi\",\"doi\":\"10.1016/j.flatc.2025.100849\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Two-dimensional MXenes and their derivatives have attracted significant attention in recent years for their potential applications in combination therapies, specifically in chemo-photothermal, chemodynamic, and photothermal/photodynamic treatments. MXenes offer distinct advantages in combination therapies due to their exceptional electrical conductivity, hydrophilicity, large surface area, tunable surface chemistry, and ability to enhance drug delivery and therapeutic efficacy through multifunctional applications. By incorporating MXenes into combination therapies, researchers have demonstrated enhanced therapeutic efficacy through synergistic mechanisms that improve drug delivery, increase localized heating, and amplify the generation of reactive oxygen species, thereby effectively targeting and eliminating cancer cells or contaminations. However, stability in biological environments remains a primary concern, as degradation can compromise their therapeutic effectiveness and safety. Ensuring biocompatibility is crucial, since the introduction of MXenes and their composites may trigger immune responses or cytotoxicity. Moreover, optimizing the synthesis of high-quality MXenes with uniform properties remains a logistical challenge, affecting reproducibility and scalability for clinical applications. By consolidating existing knowledge and identifying future directions, this review aims to advance MXene-based combination chemo-photothermal, chemodynamic, and photothermal/photodynamic therapies for cancer treatment and antibacterial applications, ultimately paving the way for innovative strategies in biomedicine and personalized medicine.</div></div>\",\"PeriodicalId\":316,\"journal\":{\"name\":\"FlatChem\",\"volume\":\"51 \",\"pages\":\"Article 100849\"},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2025-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"FlatChem\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2452262725000431\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"FlatChem","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452262725000431","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0

摘要

近年来,二维MXenes及其衍生物因其在化学-光热、化学动力学和光热/光动力联合治疗中的潜在应用而引起了人们的广泛关注。MXenes具有优异的导电性、亲水性、大表面积、可调节的表面化学性质以及通过多功能应用增强药物传递和治疗效果的能力,在联合治疗中具有明显的优势。通过将MXenes结合到联合治疗中,研究人员已经证明,通过协同机制改善药物传递、增加局部加热、增加活性氧的产生,从而有效地靶向和消除癌细胞或污染物,从而提高了治疗效果。然而,生物环境中的稳定性仍然是一个主要问题,因为降解会损害其治疗效果和安全性。确保生物相容性至关重要,因为引入MXenes及其复合材料可能引发免疫反应或细胞毒性。此外,优化合成具有统一性质的高质量MXenes仍然是一个后勤挑战,影响临床应用的可重复性和可扩展性。通过巩固现有知识和确定未来发展方向,本文旨在推进基于mxeni的化学-光热、化学动力学和光热/光动力联合疗法在癌症治疗和抗菌方面的应用,最终为生物医学和个性化医疗的创新策略铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

MXenes in combination therapy: Chemo-photothermal, chemodynamic, and photothermal/photodynamic therapies for cancer treatment and antibacterial applications

MXenes in combination therapy: Chemo-photothermal, chemodynamic, and photothermal/photodynamic therapies for cancer treatment and antibacterial applications
Two-dimensional MXenes and their derivatives have attracted significant attention in recent years for their potential applications in combination therapies, specifically in chemo-photothermal, chemodynamic, and photothermal/photodynamic treatments. MXenes offer distinct advantages in combination therapies due to their exceptional electrical conductivity, hydrophilicity, large surface area, tunable surface chemistry, and ability to enhance drug delivery and therapeutic efficacy through multifunctional applications. By incorporating MXenes into combination therapies, researchers have demonstrated enhanced therapeutic efficacy through synergistic mechanisms that improve drug delivery, increase localized heating, and amplify the generation of reactive oxygen species, thereby effectively targeting and eliminating cancer cells or contaminations. However, stability in biological environments remains a primary concern, as degradation can compromise their therapeutic effectiveness and safety. Ensuring biocompatibility is crucial, since the introduction of MXenes and their composites may trigger immune responses or cytotoxicity. Moreover, optimizing the synthesis of high-quality MXenes with uniform properties remains a logistical challenge, affecting reproducibility and scalability for clinical applications. By consolidating existing knowledge and identifying future directions, this review aims to advance MXene-based combination chemo-photothermal, chemodynamic, and photothermal/photodynamic therapies for cancer treatment and antibacterial applications, ultimately paving the way for innovative strategies in biomedicine and personalized medicine.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
FlatChem
FlatChem Multiple-
CiteScore
8.40
自引率
6.50%
发文量
104
审稿时长
26 days
期刊介绍: FlatChem - Chemistry of Flat Materials, a new voice in the community, publishes original and significant, cutting-edge research related to the chemistry of graphene and related 2D & layered materials. The overall aim of the journal is to combine the chemistry and applications of these materials, where the submission of communications, full papers, and concepts should contain chemistry in a materials context, which can be both experimental and/or theoretical. In addition to original research articles, FlatChem also offers reviews, minireviews, highlights and perspectives on the future of this research area with the scientific leaders in fields related to Flat Materials. Topics of interest include, but are not limited to, the following: -Design, synthesis, applications and investigation of graphene, graphene related materials and other 2D & layered materials (for example Silicene, Germanene, Phosphorene, MXenes, Boron nitride, Transition metal dichalcogenides) -Characterization of these materials using all forms of spectroscopy and microscopy techniques -Chemical modification or functionalization and dispersion of these materials, as well as interactions with other materials -Exploring the surface chemistry of these materials for applications in: Sensors or detectors in electrochemical/Lab on a Chip devices, Composite materials, Membranes, Environment technology, Catalysis for energy storage and conversion (for example fuel cells, supercapacitors, batteries, hydrogen storage), Biomedical technology (drug delivery, biosensing, bioimaging)
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信