具有机械和充电后抗菌活性的超快充电二氧化锰纳米片/碳纤维

IF 9.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-03-15 DOI:10.1021/acs.nanolett.4c06179

Yang Zou, Qinrong He, Yudong Song, Xiangyu Yang, Xinjian Shi, Shengyan Yin, Song Liang, Zhenning Liu, Hang Sun

{"title":"具有机械和充电后抗菌活性的超快充电二氧化锰纳米片/碳纤维","authors":"Yang Zou, Qinrong He, Yudong Song, Xiangyu Yang, Xinjian Shi, Shengyan Yin, Song Liang, Zhenning Liu, Hang Sun","doi":"10.1021/acs.nanolett.4c06179","DOIUrl":null,"url":null,"abstract":"Postcharging antibacterials have shown good application prospects in combating bacterial infections through electrical interaction. Herein, manganese oxide nanosheets in situ grown on carbon fibers (CM) are designed to perform the integration of mechanical intervention and postcharging therapy for efficient bacterial killing. This electrode disrupts bacterial membranes via sharp-edged microstructures. After charging at a low voltage in an ultrashort time, the charged CM affects the extracellular electron transfer (EET) of bacteria during the discharge process to kill the bacteria. Due to the dual-antibacterial mode, after charging at −1 V (vs saturated calomel electrode, SCE) for only 50.4 ± 3 s, the bacteria lethality rates of the CM against Escherichia coli and Staphylococcus aureus within 0.5 h both exceed 98%. Our developed ultrafast negatively charged CM exhibits high antibacterial activity and low cytotoxicity to fibroblast cells, providing a non-antibiotic approach to combat bacterial infection.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"55 1","pages":""},"PeriodicalIF":9.1000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ultrafast Charged MnO2 Nanosheets/Carbon Fiber with Mechanical and Postcharging Antibacterial Activity\",\"authors\":\"Yang Zou, Qinrong He, Yudong Song, Xiangyu Yang, Xinjian Shi, Shengyan Yin, Song Liang, Zhenning Liu, Hang Sun\",\"doi\":\"10.1021/acs.nanolett.4c06179\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Postcharging antibacterials have shown good application prospects in combating bacterial infections through electrical interaction. Herein, manganese oxide nanosheets in situ grown on carbon fibers (CM) are designed to perform the integration of mechanical intervention and postcharging therapy for efficient bacterial killing. This electrode disrupts bacterial membranes via sharp-edged microstructures. After charging at a low voltage in an ultrashort time, the charged CM affects the extracellular electron transfer (EET) of bacteria during the discharge process to kill the bacteria. Due to the dual-antibacterial mode, after charging at −1 V (vs saturated calomel electrode, SCE) for only 50.4 ± 3 s, the bacteria lethality rates of the CM against Escherichia coli and Staphylococcus aureus within 0.5 h both exceed 98%. Our developed ultrafast negatively charged CM exhibits high antibacterial activity and low cytotoxicity to fibroblast cells, providing a non-antibiotic approach to combat bacterial infection.\",\"PeriodicalId\":53,\"journal\":{\"name\":\"Nano Letters\",\"volume\":\"55 1\",\"pages\":\"\"},\"PeriodicalIF\":9.1000,\"publicationDate\":\"2025-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano Letters\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1021/acs.nanolett.4c06179\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Letters","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acs.nanolett.4c06179","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

后充抗菌药物在利用电相互作用对抗细菌感染方面显示出良好的应用前景。在此，在碳纤维（CM）上原位生长的氧化锰纳米片被设计用于执行机械干预和后充电治疗的集成，以有效地杀死细菌。这种电极通过边缘锋利的微结构破坏细菌膜。在超短时间内以低电压充电后，带电的CM在放电过程中影响细菌的胞外电子转移（EET），从而杀死细菌。由于采用双抗菌模式，在−1 V （vs饱和甘汞电极，SCE）下充电仅50.4±3 s， CM在0.5 h内对大肠杆菌和金黄色葡萄球菌的致死率均超过98%。我们开发的超快负电荷CM对成纤维细胞具有高抗菌活性和低细胞毒性，提供了一种非抗生素的方法来对抗细菌感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ultrafast Charged MnO2 Nanosheets/Carbon Fiber with Mechanical and Postcharging Antibacterial Activity

查看原文本刊更多论文

Ultrafast Charged MnO2 Nanosheets/Carbon Fiber with Mechanical and Postcharging Antibacterial Activity

Postcharging antibacterials have shown good application prospects in combating bacterial infections through electrical interaction. Herein, manganese oxide nanosheets in situ grown on carbon fibers (CM) are designed to perform the integration of mechanical intervention and postcharging therapy for efficient bacterial killing. This electrode disrupts bacterial membranes via sharp-edged microstructures. After charging at a low voltage in an ultrashort time, the charged CM affects the extracellular electron transfer (EET) of bacteria during the discharge process to kill the bacteria. Due to the dual-antibacterial mode, after charging at −1 V (vs saturated calomel electrode, SCE) for only 50.4 ± 3 s, the bacteria lethality rates of the CM against Escherichia coli and Staphylococcus aureus within 0.5 h both exceed 98%. Our developed ultrafast negatively charged CM exhibits high antibacterial activity and low cytotoxicity to fibroblast cells, providing a non-antibiotic approach to combat bacterial infection.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.