{"title":"转录调节蛋白SIN3 （YOL004W）影响酿酒酵母的突变率。","authors":"Alexandra Eftimie, Damon Meyer","doi":"10.17912/micropub.biology.001521","DOIUrl":null,"url":null,"abstract":"<p><p><i>SIN3</i> (YOL004W) codes for a protein in <i>Saccharomyces cerevisiae</i> which is suggested to function as a broad cellular transcription regulator through the binding of histone deacetylases and other enzymes to form a large protein complex that modifies chromatin. In addition, <i>SIN3</i> has also demonstrated potential roles in epigenetic silencing, DNA methylation, and centromere function. Here we report a new role of <i>SIN3</i> in affecting mutation rates within the <i>CAN1</i> reporter gene, suggesting an impact on genome stability.</p>","PeriodicalId":74192,"journal":{"name":"microPublication biology","volume":"2025 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904613/pdf/","citationCount":"0","resultStr":"{\"title\":\"Transcription Regulatory Protein <i>SIN3</i> (YOL004W) Influences Mutation Rates in <i>Saccharomyces cerevisiae</i>.\",\"authors\":\"Alexandra Eftimie, Damon Meyer\",\"doi\":\"10.17912/micropub.biology.001521\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>SIN3</i> (YOL004W) codes for a protein in <i>Saccharomyces cerevisiae</i> which is suggested to function as a broad cellular transcription regulator through the binding of histone deacetylases and other enzymes to form a large protein complex that modifies chromatin. In addition, <i>SIN3</i> has also demonstrated potential roles in epigenetic silencing, DNA methylation, and centromere function. Here we report a new role of <i>SIN3</i> in affecting mutation rates within the <i>CAN1</i> reporter gene, suggesting an impact on genome stability.</p>\",\"PeriodicalId\":74192,\"journal\":{\"name\":\"microPublication biology\",\"volume\":\"2025 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904613/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"microPublication biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17912/micropub.biology.001521\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"microPublication biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17912/micropub.biology.001521","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Transcription Regulatory Protein SIN3 (YOL004W) Influences Mutation Rates in Saccharomyces cerevisiae.
SIN3 (YOL004W) codes for a protein in Saccharomyces cerevisiae which is suggested to function as a broad cellular transcription regulator through the binding of histone deacetylases and other enzymes to form a large protein complex that modifies chromatin. In addition, SIN3 has also demonstrated potential roles in epigenetic silencing, DNA methylation, and centromere function. Here we report a new role of SIN3 in affecting mutation rates within the CAN1 reporter gene, suggesting an impact on genome stability.
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