{"title":"复杂性状的缺失调控效应：远端变异的贡献","authors":"Sool Lee, Hakhamanesh Mostafavi","doi":"10.1016/j.xgen.2025.100809","DOIUrl":null,"url":null,"abstract":"<p><p>Most genetic effects on complex traits lie in non-coding regions, yet many show no regulatory activity in standard gene expression assays. In this issue of Cell Genomics, Arthur et al.<sup>1</sup> add early development-like cell types and chromatin assays, showing that distal variants missed in expression assays partly explain this discrepancy.</p>","PeriodicalId":72539,"journal":{"name":"Cell genomics","volume":"5 3","pages":"100809"},"PeriodicalIF":11.1000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Missing regulatory effects on complex traits: Contribution of distal variants.\",\"authors\":\"Sool Lee, Hakhamanesh Mostafavi\",\"doi\":\"10.1016/j.xgen.2025.100809\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Most genetic effects on complex traits lie in non-coding regions, yet many show no regulatory activity in standard gene expression assays. In this issue of Cell Genomics, Arthur et al.<sup>1</sup> add early development-like cell types and chromatin assays, showing that distal variants missed in expression assays partly explain this discrepancy.</p>\",\"PeriodicalId\":72539,\"journal\":{\"name\":\"Cell genomics\",\"volume\":\"5 3\",\"pages\":\"100809\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-03-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell genomics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.xgen.2025.100809\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell genomics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.xgen.2025.100809","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Missing regulatory effects on complex traits: Contribution of distal variants.
Most genetic effects on complex traits lie in non-coding regions, yet many show no regulatory activity in standard gene expression assays. In this issue of Cell Genomics, Arthur et al.1 add early development-like cell types and chromatin assays, showing that distal variants missed in expression assays partly explain this discrepancy.
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