欧洲人对异种移植研究的贡献:猪器官异种移植。

IF 2.7 3区 医学 Q1 SURGERY
Transplant International Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI:10.3389/ti.2025.14041
Zuzanna Iwanczyk, Krish Vasudev, Emanuele Cozzi, David K C Cooper
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引用次数: 0

摘要

异种移植有着丰富的历史,欧洲的先驱们为该领域的许多突破奠定了基础。猪器官异种移植为全球死亡人类供体器官短缺提供了解决方案,同时允许对供体移植本身进行修改。这一领域一直吸引着人们的兴趣,特别是随着最近更简单、更快速的基因工程技术的出现。这篇综述强调了欧洲研究人员在异种移植方面的贡献,包括猪肾、心脏、肝脏和肺移植。研究主要集中在(1)鉴定和删除关键的异种抗原,并通过表达人类“保护性”蛋白来修饰源猪,以及(2)测试新的免疫抑制方案。这些贡献在推进异种移植从实验室到早期临床实验中发挥了关键作用。欧洲人还解决了异种人畜共患病感染的潜在风险和监管挑战。总结了欧洲各研究组的研究工作。几位欧洲研究人员永久或临时迁往美国的机构,他们的洞察力和创新也得到了强调。虽然我们的目标是在这篇文章中承认欧洲医生和科学家的重大贡献,但它并不是所有影响该领域的人的详尽名单。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contributions of Europeans to Xenotransplantation Research: 1. Pig Organ Xenotransplantation.

Xenotransplantation has a rich history, marked by European pioneers who laid the groundwork for many breakthroughs in the field. Pig organ xenotransplantation offers a solution to the global shortage of deceased human donor organs, whilst allowing the modification of the donor graft itself. The field has continued to garner interest, particularly with the recent advent of simpler and faster genetic-engineering technologies. This review highlights the contributions of European researchers to xenotransplantation, spanning pig kidney, heart, liver, and lung transplantation. Research has focused on (i) identifying and deleting key xenoantigens and modifying the source pig by expression of human "protective" proteins and (ii) testing novel immunosuppressive regimens. These contributions have played key roles in advancing xenotransplantation from the laboratory to early clinical experiments. Europeans have also addressed the potential risks of xenozoonotic infections and the regulatory challenges. The research endeavours of groups in Europe are summarized. Several European researchers moved either permanently or temporarily to US institutions, and their insight and innovations are also highlighted. While we aim to recognize the significant contributions of European physicians and scientists in this article, it is not an exhaustive list of all those who have influenced the field.

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来源期刊
Transplant International
Transplant International 医学-外科
CiteScore
4.70
自引率
6.50%
发文量
211
审稿时长
3-8 weeks
期刊介绍: The aim of the journal is to serve as a forum for the exchange of scientific information in the form of original and high quality papers in the field of transplantation. Clinical and experimental studies, as well as editorials, letters to the editors, and, occasionally, reviews on the biology, physiology, and immunology of transplantation of tissues and organs, are published. Publishing time for the latter is approximately six months, provided major revisions are not needed. The journal is published in yearly volumes, each volume containing twelve issues. Papers submitted to the journal are subject to peer review.
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